Comparative effects of alpha-1 and alpha-2 adrenoceptors in modulation of coronary flow during exercise

J. R. Strader, Patricia A. Gwirtz, C. E. Jones

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

During submaximal exercise, an alpha adrenergic vasoconstriction that opposes metabolic dilation exists in the coronary circulation. Fifteen dogs were given i.c. injections of prazosin (0.5 mg) or yohimbine (0.7 mg) to determine the participation of alpha1 and alpha2 adrenoceptors in the vasoconstriction during exercise. All dogs were chronically instrumented to measure left circumflex blood flow, heart rate, regional left ventricular function and global left ventricular function. The experimental protocol consisted of a graded exercise regimen during which, at the highest level of exercise an alpha antagonist was given i.c. Exercise significantly increased heart rate, left ventricular pressure, dP/dt, systolic shortening and rate of shortening, and coronary blood flow. After the prazosin injection there was an increase in circumflex blood flow (25 ± 3%) as well as regional (38 ± 6%) and global (20 ± 3%) contractile function. However, there was no change in circumflex blood flow or myocardial function after yohimbine. These data indicate that during exercise the sympathetic constrictor tone in the coronary circulation is mediated primarily by alpha1 adrenoceptors, with little or no involvement from alpha2 adrenoceptors.

Original languageEnglish
Pages (from-to)772-778
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume246
Issue number2
StatePublished - 1 Jan 1988

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