@article{9e6b58939430451e9253fcd07a0f5f60,
title = "Combining Select Blood-Based Biomarkers with Neuropsychological Assessment to Detect Mild Cognitive Impairment among Mexican Americans",
abstract = "Background: Recent work has supported use of blood-based biomarkers in detection of amnestic mild cognitive impairment (MCI). Inclusion of neuropsychological measures has shown promise in enhancing utility of biomarkers to detect disease. Objective: The present study sought to develop cognitive-biomarker profiles for detection of MCI. Methods: Data were analyzed on 463 participants (normal control n = 378; MCI n = 85) from HABLE. Random forest analyses determined proteomic profile of MCI. Separate linear regression analyses determined variance accounted for by select biomarkers per neuropsychological measure. When neuropsychological measure with the least shared variance was identified, it was then combined with select biomarkers to create a biomarker-cognitive profile. Results: The biomarker-cognitive profile was 90% accurate in detecting MCI. Among amnestic MCI cases, the detection accuracy of the biomarker-cognitive profile was 92% and increased to 94% with demographic variables. Conclusion: The biomarker-cognitive profile for MCI was highly accurate in its detection with use of only five biomarkers. ",
keywords = "Blood based, biomarkers, mexican american, mild cognitive impairment, neuropsychology",
author = "Melissa Petersen and James Hall and Thomas Parsons and Leigh Johnson and Sid O'Bryant",
note = "Funding Information: The molecular neuropsychology approach utilized in this study has shown utility in both aMCI and AD, which lends support for its application among cases of prodromal AD (i.e., MCI cases who are also amyloid positive). An ongoing study focused on the detection of AD within primary care (Alzheimer{\textquoteright}s Disease in Primary Care study) is currently collecting data, which will allow for application of this approach to be evaluated among this diagnostic group who are most likely to convert to dementia due to AD. The 2015 Gerontological Society of America workgroup reported that “older adults are inadequately assessed for cognitive impairment during routine visits with their primary care providers” [46] despite recommendations set by the Centers for Medicare and Medicaid Services, which requires that primary care providers conduct a cognitive exam as a part of their annual Research reported here was supported by the National Institute on Aging of the National Institutes of Health under award number R01AG054073. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The research team also thanks the local Fort Worth community and participants of the Health & Aging Brain Study. Publisher Copyright: {\textcopyright} 2020 - IOS Press and the authors. All rights reserved.",
year = "2020",
doi = "10.3233/JAD-191264",
language = "English",
volume = "75",
pages = "739--750",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "3",
}