Combinatorial lead optimization of a neuropeptide FF antagonist

Keyphrases

• Amino Acids 33%
• Anti-opioid 33%
• Central Nervous System 33%
• Combinatorial Optimization 33%
• Competitive Binding 33%
• Cysteine 33%
• Dansyl 66%
• Dimethylamino 66%
• Glutamine 33%
• High Affinity 33%
• Lead Optimization 100%
• Mixing Method 33%
• Neuropeptide FF 100%
• NPFF Receptors 33%
• Opiate Withdrawal 33%
• Phase Split 33%
• Proline 33%
• Proline Residue 33%
• Secondary Amino Group 33%
• Solid Phase 33%
• Systemic Administration 33%
• Therapeutic Leads 33%
• Tripeptide 33%

Chemistry

• Amino Acid 33%
• Arginine 66%
• Cysteine 33%
• Glutamine 33%
• Gly-Ser 33%
• Lead Compound 33%
• Neuropeptide FF 100%
• Pro-Gln 33%
• Proline 33%
• Proline Residue 33%
• Secondary Amino Group 33%
• Tripeptide 33%