Colchicine: A novel positive allosteric modulator of the human 5-Hydroxytryptamine _3A receptor

Keyphrases

• Positive Allosteric Modulator 100%
• 5-hydroxytryptamine3 Receptor 100%
• Colchicine 100%
• 5-hydroxytryptamine 20%
• Receptor Function 20%
• Functional Impact 10%
• Ligand-binding Domain 10%
• Incubation 10%
• Methyl 10%
• Pre-incubation 10%
• Radioligand Binding Assay 10%
• N-terminus 10%
• IC50 10%
• Voltage Clamp Technique 10%
• Xenopus Oocytes 10%
• Human Receptor 10%
• Two-electrode Voltage Clamp 10%
• Gating Mechanism 10%
• Microtubules 10%
• Azabicyclo 10%
• Chimeric Antigen Receptor T Cells (CAR-T) 10%
• Receptor Binding Studies 10%
• Co-application 10%
• Oocyte Membrane 10%
• Cold Temperature 10%
• Indazole-3-carboxamides 10%
• 1H-indazole 10%
• Bidirectional Modulation 10%
• Depolymerizing 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Positive Allosteric Modulator 100%
• Serotonin 3A Receptor 100%
• Colchicine 100%
• Receptor 60%
• Serotonin 20%
• Radioligand 10%
• IC50 10%
• Electrolyte Solution 10%
• Carboxamide 10%
• Xenopus laevis 10%
• Indazole Derivative 10%

Biochemistry, Genetics and Molecular Biology

• Serotonin 100%
• N-Terminus 20%
• Ligand Binding Domain 20%
• Radioligand 20%
• Receptor Binding 20%
• IC50 20%
• Binding Study 20%
• Voltage Clamp 20%
• Xenopus laevis 20%
• Cold 20%