Cognitive dysfunction and the 25-item National Eye Institute Visual Function Questionnaire

Sima Mozdbar, Jessica Alber, Subhash Aryal, Leigh Johnson, Alina Moroz, Mohammad Rashik, Amir Mostafavi, Sid O'Bryant

Research output: Contribution to journalArticlepeer-review


Introduction: Visual function and cognitive impairment are interrelated; however, little is known about the impact of modifying treatable vision impairment on the development of cognitive dysfunction. This study examines the relationship between cognition and self-reported visual function using the National Eye Institute's Visual Function Questionnaire (NEI VFQ). Methods: Participants completed the NEI VFQ 25-Item questionnaire as well as the Mini-Mental State Examination (MMSE). Additionally, all participants were assigned a consensus clinical diagnosis based on established criteria. We used a general linear model and analysis of variance approach to compare means between multiple groups. Results: A significant association between overall composite score on the NEI VFQ and total MMSE score was revealed (P = 0.04). On average, for every 1-point increase in MMSE score, the overall composite score increased by 0.40 units (95% confidence interval: 0.03–0.77). Discussion: Reduced visual function should raise concerns about cognitive decline and prompt additional assessment.

Original languageEnglish
Article numbere12378
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Issue number1
StatePublished - 2022


  • Alzheimer's disease
  • Mini-Mental State Examination
  • National Eye Institute Visual Function Questionnaire
  • cognitive dysfunction
  • visual function


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