Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The purpose of this study was to determine if intake of the antioxidants coenzyme Q10 (CoQ10) or α-tocopherol (Toc), either alone or in combination, could ameliorate cognitive and psychomotor impairments of aged mice, as well as reduce oxidative burden in tissues. For a period of 10weeks, male C57BL/6J mice (3 or 18months) were fed either a control diet, or one of three diets supplemented with Toc, CoQ10 or their combination, and were tested for cognitive and psychomotor functions. Old mice on the Toc or Toc/CoQ10 diets showed improved coordinated running performance. Mice on the diet containing Toc/CoQ10 demonstrated improved performance in the discriminated avoidance task. CoQ10 and Toc alone also resulted in improved performance, albeit to a lesser degree. Protein damage was decreased especially when the mice received Toc+CoQ10 combination. Overall, these results suggest that, Toc and CoQ supplementation can ameliorate age-related impairment and reduce protein oxidation. Moreover, concurrent supplementation of CoQ10 and Toc may be more effective than either antioxidant alone.

Original languageEnglish
Pages (from-to)208-218
Number of pages11
JournalExperimental Gerontology
Volume58
DOIs
StatePublished - 1 Jan 2014

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coenzyme Q10
Tocopherols
Nutrition
Diet
Antioxidants
Psychomotor Disorders

Keywords

  • Antioxidants
  • Behavior
  • Cognitive function
  • Mitochondria
  • Motor function
  • Oxidative stress
  • Vitamin E

Cite this

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abstract = "The purpose of this study was to determine if intake of the antioxidants coenzyme Q10 (CoQ10) or α-tocopherol (Toc), either alone or in combination, could ameliorate cognitive and psychomotor impairments of aged mice, as well as reduce oxidative burden in tissues. For a period of 10weeks, male C57BL/6J mice (3 or 18months) were fed either a control diet, or one of three diets supplemented with Toc, CoQ10 or their combination, and were tested for cognitive and psychomotor functions. Old mice on the Toc or Toc/CoQ10 diets showed improved coordinated running performance. Mice on the diet containing Toc/CoQ10 demonstrated improved performance in the discriminated avoidance task. CoQ10 and Toc alone also resulted in improved performance, albeit to a lesser degree. Protein damage was decreased especially when the mice received Toc+CoQ10 combination. Overall, these results suggest that, Toc and CoQ supplementation can ameliorate age-related impairment and reduce protein oxidation. Moreover, concurrent supplementation of CoQ10 and Toc may be more effective than either antioxidant alone.",
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Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice. / Shetty, Ritu Anand; Ikonne, Uzoma S.; Forster, Michael J.; Sumien, Nathalie.

In: Experimental Gerontology, Vol. 58, 01.01.2014, p. 208-218.

Research output: Contribution to journalArticle

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