Abstract
The purpose of this study was to determine if intake of the antioxidants coenzyme Q10 (CoQ10) or α-tocopherol (Toc), either alone or in combination, could ameliorate cognitive and psychomotor impairments of aged mice, as well as reduce oxidative burden in tissues. For a period of 10weeks, male C57BL/6J mice (3 or 18months) were fed either a control diet, or one of three diets supplemented with Toc, CoQ10 or their combination, and were tested for cognitive and psychomotor functions. Old mice on the Toc or Toc/CoQ10 diets showed improved coordinated running performance. Mice on the diet containing Toc/CoQ10 demonstrated improved performance in the discriminated avoidance task. CoQ10 and Toc alone also resulted in improved performance, albeit to a lesser degree. Protein damage was decreased especially when the mice received Toc+CoQ10 combination. Overall, these results suggest that, Toc and CoQ supplementation can ameliorate age-related impairment and reduce protein oxidation. Moreover, concurrent supplementation of CoQ10 and Toc may be more effective than either antioxidant alone.
Original language | English |
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Pages (from-to) | 208-218 |
Number of pages | 11 |
Journal | Experimental Gerontology |
Volume | 58 |
DOIs | |
State | Published - Oct 2014 |
Keywords
- Antioxidants
- Behavior
- Cognitive function
- Mitochondria
- Motor function
- Oxidative stress
- Vitamin E