Co-expression of the 5-HT3B subunit with the 5-HT3A receptor reduces alcohol sensitivity

Volodya Hayrapetyan, Monica Jenschke, Glenn H. Dillon, Tina K. Machu

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Allosteric modulation of mouse 5-Hydroxytryptamine3A (5-HT 3A) and 5-HT3A/B receptor function by ethanol and trichloroethanol (TCEt) was assessed in HEK293 cells with whole cell patch-clamp electrophysiological recordings. Ethanol enhanced 5-HT3A receptor function, but had no effect on mouse 5-HT3A/B receptor mediated currents. The enhancing action of trichloroethanol (TCEt) on mouse 5-HT 3A/B receptor function was much less than that observed in the mouse 5-HT3A receptor. Where alcohol-induced increases in peak amplitude were observed, the slope of the 20-80% rising phase of current onset was also enhanced, suggesting that increases in activation rate may be one mechanism through which alcohols enhance function of the 5-HT3 receptors.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalMolecular Brain Research
Volume142
Issue number2
DOIs
StatePublished - 14 Dec 2005

Keywords

  • 5-HT
  • 5-HT
  • Ethanol
  • Ligand-gated ion channel
  • Trichloroethanol

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