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Clozapine pharmacokinetics and pharmacodynamics studied with CYP1A2-null mice
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Dive into the research topics of 'Clozapine pharmacokinetics and pharmacodynamics studied with CYP1A2-null mice'. Together they form a unique fingerprint.
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Keyphrases
Adverse Effects
9%
Area under the Curve
27%
Behavioral Parameters
9%
Blood Samples
9%
Clozapine
100%
Clozapine-N-oxide
18%
Cytochrome P450 1A2 (CYP1A2)
100%
Demethylation
9%
Extensive Metabolizer
9%
HPLC with UV Detection
9%
Intraperitoneal Injection
9%
Major Determinants
9%
Motor Impairment
9%
Myoclonus
18%
N-oxidation
9%
Null Mice
100%
One Percent
9%
Pharmacodynamics
100%
Pharmacokinetics
100%
Poor Metabolizer
9%
Sedation
9%
Seizure
9%
Wild Mice
45%
Pharmacology, Toxicology and Pharmaceutical Science
Adverse Event
9%
Clozapine
100%
Clozapine N Oxide
18%
CYP1A2
100%
Desmethylclozapine
18%
High Performance Liquid Chromatography
9%
Intraperitoneal Injection
9%
Knockout Mouse
100%
Motor Dysfunction
9%
Myoclonus
18%
Pharmacodynamics
100%
Pharmacokinetics
100%
Wild Type Mouse
45%