Clinical implications of increased antipsychotic plasma concentrations upon anticonvulsant cessation

Michael W. Jann; George S. Fidone; Jose M. Hernandez; Suchakorn Amrung; Chester M. Davis

doi:10.1016/0165-1781(89)90043-7

Clinical implications of increased antipsychotic plasma concentrations upon anticonvulsant cessation

Michael W. Jann, George S. Fidone, Jose M. Hernandez, Suchakorn Amrung, Chester M. Davis

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Plasma antipsychotic concentrations were measured in five patients when their anticonvulsant medications were discontinued. Plasma antipsychotic concentrations increased by two- to five-fold at 4 weeks after cessation. All patients demonstrated either moderate or marked improvement as antipsychotic plasma concentrations increased. Four patients experienced extrapyramidal side effects within 30 days of anticonvulsant discontinuation. Careful monitoring of clinical symptoms, adverse effects, and plasma antipsychotic concentrations is recommended.

Original language	English
Pages (from-to)	153-159
Number of pages	7
Journal	Psychiatry Research
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(89)90043-7
State	Published - 1 Jan 1989

Keywords

anticonvulsant
Antipsychotic
carbamazepine
phenytoin
plasma concentrations

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abstract = "Plasma antipsychotic concentrations were measured in five patients when their anticonvulsant medications were discontinued. Plasma antipsychotic concentrations increased by two- to five-fold at 4 weeks after cessation. All patients demonstrated either moderate or marked improvement as antipsychotic plasma concentrations increased. Four patients experienced extrapyramidal side effects within 30 days of anticonvulsant discontinuation. Careful monitoring of clinical symptoms, adverse effects, and plasma antipsychotic concentrations is recommended.",

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AU - Amrung, Suchakorn

AU - Davis, Chester M.

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AB - Plasma antipsychotic concentrations were measured in five patients when their anticonvulsant medications were discontinued. Plasma antipsychotic concentrations increased by two- to five-fold at 4 weeks after cessation. All patients demonstrated either moderate or marked improvement as antipsychotic plasma concentrations increased. Four patients experienced extrapyramidal side effects within 30 days of anticonvulsant discontinuation. Careful monitoring of clinical symptoms, adverse effects, and plasma antipsychotic concentrations is recommended.

KW - anticonvulsant

KW - Antipsychotic

KW - carbamazepine

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Clinical implications of increased antipsychotic plasma concentrations upon anticonvulsant cessation

Abstract

Keywords

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