TY - JOUR
T1 - Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases
AU - Ma, Jingxi
AU - Gao, Baobing
AU - Zhang, Keming
AU - Zhang, Qinbin
AU - Jia, Gongwei
AU - Li, J.
AU - Li, Changqing
AU - Yan, Liang Jun
AU - Cai, Zhiyou
N1 - Funding Information:
This work was supported by the Science and Technology Planning Project of Yuzhong District of Chongqing [grant number 20180136 ].
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/11
Y1 - 2019/11
N2 - Recent animal studies on heterochronic parabiosis (a technique combining the blood circulation of two animals) have revealed that young blood has a powerful rejuvenating effect on brain aging. Circulating factors, especially growth differentiation factor 11 (GDF11) and C-C motif chemokine 11 (CCL11), may play a key role in this effect, which inspires hope for novel approaches to treating age-related cerebral diseases in humans, such as neurodegenerative and neurovascular diseases. Recently, attempts have begun to translate these astonishing and exciting findings from mice to humans and from bench to bedside. However, increasing reports have shown contradictory data, questioning the capacity of these circulating factors to reverse age-related brain dysfunction. In this review, we summarize the current research on the role of young blood, as well as the circulating factors GDF11 and CCL11, in the aging brain and age-related cerebral diseases. We highlight recent controversies, discuss related challenges and provide a future outlook.
AB - Recent animal studies on heterochronic parabiosis (a technique combining the blood circulation of two animals) have revealed that young blood has a powerful rejuvenating effect on brain aging. Circulating factors, especially growth differentiation factor 11 (GDF11) and C-C motif chemokine 11 (CCL11), may play a key role in this effect, which inspires hope for novel approaches to treating age-related cerebral diseases in humans, such as neurodegenerative and neurovascular diseases. Recently, attempts have begun to translate these astonishing and exciting findings from mice to humans and from bench to bedside. However, increasing reports have shown contradictory data, questioning the capacity of these circulating factors to reverse age-related brain dysfunction. In this review, we summarize the current research on the role of young blood, as well as the circulating factors GDF11 and CCL11, in the aging brain and age-related cerebral diseases. We highlight recent controversies, discuss related challenges and provide a future outlook.
KW - C-C motif chemokine 11
KW - Circulating factor
KW - Growth differentiation factor 11
KW - Neurodegenerative diseases
KW - Neurovascular diseases
KW - Young blood
UR - http://www.scopus.com/inward/record.url?scp=85070408450&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2019.08.004
DO - 10.1016/j.brainresbull.2019.08.004
M3 - Review article
C2 - 31400495
AN - SCOPUS:85070408450
SN - 0361-9230
VL - 153
SP - 15
EP - 23
JO - Brain Research Bulletin
JF - Brain Research Bulletin
ER -