Circulating Cell-Free Mitochondrial DNA in Pregnancy

Jessica L. Bradshaw, Spencer C. Cushen, Nicole R. Phillips, Styliani Goulopoulou

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss the temporal changes of ccf-mtDNA during pregnancy and its potential contribution to adverse pregnancy outcomes in pregnancy complications.

Original languageEnglish
Pages (from-to)187-196
Number of pages10
JournalPhysiology
Volume37
Issue number4
DOIs
StatePublished - Jul 2022

Keywords

  • circulating DNA
  • gestation
  • maternal
  • mitochondria
  • preeclampsia

Fingerprint

Dive into the research topics of 'Circulating Cell-Free Mitochondrial DNA in Pregnancy'. Together they form a unique fingerprint.

Cite this