Chronic inhibition of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as an approach to managing diabetic oxidative stress

Medicine & Life Sciences

• Dihydrolipoamide Dehydrogenase 97%
• Oxidative Stress 45%
• Type 2 Diabetes Mellitus 17%
• Decarboxylation 10%
• Acetyl Coenzyme A 10%
• Reactive Nitrogen Species 10%
• Adenine 9%
• triphosphoric acid 9%
• Pyruvic Acid 8%
• Metabolic Networks and Pathways 7%
• Oxidation-Reduction 7%
• Reactive Oxygen Species 6%
• Animal Models 5%
• Stroke 5%
• Glucose 4%
• Enzymes 4%
• Wounds and Injuries 3%

Chemical Compounds

• Dihydrolipoamide 100%
• Oxidative Stress 61%
• Metabolic 12%
• Reactive Nitrogen Species 10%
• Acetyl-CoA 9%
• Pyruvate 8%
• Decarboxylation 7%
• Reactive Oxygen Metabolite 7%
• Adenine 7%
• Protective 6%
• Pharmacological Metabolism 6%
• Antioxidant Agent 5%
• Glucose 5%