Choosing Relatives for DNA Identification of Missing Persons

Jianye Ge, Bruce Budowle, Ranajit Chakraborty

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

DNA-based analysis is integral to missing person identification cases. When direct references are not available, indirect relative references can be used to identify missing persons by kinship analysis. Generally, more reference relatives render greater accuracy of identification. However, it is costly to type multiple references. Thus, at times, decisions may need to be made on which relatives to type. In this study, pedigrees for 37 common reference scenarios with 13 CODIS STRs were simulated to rank the information content of different combinations of relatives. The results confirm that first-order relatives (parents and fullsibs) are the most preferred relatives to identify missing persons; fullsibs are also informative. Less genetic dependence between references provides a higher on average likelihood ratio. Distant relatives may not be helpful solely by autosomal markers. But lineage-based Y chromosome and mitochondrial DNA markers can increase the likelihood ratio or serve as filters to exclude putative relationships.

Original languageEnglish
JournalJournal of Forensic Sciences
Volume56
Issue numberSUPPL. 1
DOIs
StatePublished - 1 Jan 2011

Keywords

  • DNA identification
  • Forensic science
  • Missing person
  • Mitochondrial DNA
  • Pedigree likelihood ratio
  • Posterior odds
  • Short tandem repeats
  • Simulation
  • Y chromosome

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