Cholesterol metabolism in the rat following lesions of the diencephalon

Michael Oglesby, Andras G. Lacko, E. Harrell, J. Jordan

Research output: Contribution to journalArticlepeer-review


In rats, bilateral electrolytic lesions of either the ventromedial hypothalamus or the septal nuclei, when combined with a high-cholesterol diet, produced elevation of total plasma cholesterol. The similar pattern of results produced by lesions in two discrete brain regions suggests that altered cholesterol metabolism may be a consequence of the common behavior, aggression, that these lesions produce. In addition, high-density lipoprotein cholesterol, when expressed as a percentage of total plasma cholesterol, was lower in rats fed a high-cholesterol diet.

Original languageEnglish
Pages (from-to)473-485
Number of pages13
Issue number6
StatePublished - 1 Jan 1979


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