Chip-based nanoelectrospray ionization with Fourier transform mass spectrometric detection to screen for local anesthetics intended to mask limb sore in walking horses

Szabolcs Szarka, Laszlo Prokai

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

We report a high-throughput chip-based nanoelectrospray ionization method coupled with Fourier transform mass spectrometry to screen for local anesthetics in samples collected by swabbing. These drugs have been used to mask pain on the limbs of walking horses after forbidden practices of soring or physical abuse. Optimized for lidocaine, the method afforded sub-ppm mass accuracy for nine local anesthetics included in the study. From doped cotton swabs, two third and all of the analytes were detected after adding 10ng and 100ng of each drug, respectively. Benzocaine and/or lidocaine were found on positive swab samples collected during walking horse competitions.

Original languageEnglish
Pages (from-to)533-537
Number of pages5
JournalJournal of Mass Spectrometry
Volume50
Issue number3
DOIs
StatePublished - 1 Jan 2015

Fingerprint

Lidocaine
Local Anesthetics
Ionization
Masks
Fourier transforms
Benzocaine
Pharmaceutical Preparations
Cotton
Mass spectrometry
Throughput

Keywords

  • FTICR
  • local anesthetics
  • nanoelectrospray ionization
  • screening
  • walking horses

Cite this

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Chip-based nanoelectrospray ionization with Fourier transform mass spectrometric detection to screen for local anesthetics intended to mask limb sore in walking horses. / Szarka, Szabolcs; Prokai, Laszlo.

In: Journal of Mass Spectrometry, Vol. 50, No. 3, 01.01.2015, p. 533-537.

Research output: Contribution to journalArticleResearchpeer-review

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