Chemokine receptors in HIV-1 infection of the central nervous system

Dana Gabuzda, Jianglin He, Asa Ohagen, Anne Valérie Vallat

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Several members of the chemokine receptor are used as coreceptors for HIV-1 infection in the central nervous system (CNS). CCR5 and CCR3 are coreceptors together with CD4 for HIV-1 infection of microglia, the major target for HIV-1 infection in the CNS. Microglia express CXCR4, but their infection by HIV-1 viruses that use only CXCR4 as a coreceptor is relatively inefficient. CXCR4 is also expressed in subpopulations of neurons that are resistant to HIV-1 infection. Additional orphan chemokine receptors that can mediate HIV-1 or SIV entry are expressed in the brain or neurally-driven cell lines, but their role in CNS infection has not been defined. The pattern of chemokine receptor expression in the brain is likely to determine the tropism of HIV-1 for particular CNS target cells and to impact inflammatory and degenerative mechanisms associated with CNS infection.

Original languageEnglish
Pages (from-to)203-213
Number of pages11
JournalSeminars in Immunology
Volume10
Issue number3
DOIs
StatePublished - Jun 1998

Keywords

  • Brain
  • Chemokine receptor
  • Chemokines
  • HIV-1
  • Microglia

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