Chemokine CXCL8 promotes HIV-1 replication in human monocyte-derived macrophages and primary microglia via nuclear factor-κB pathway

Keyphrases

• Human Immunodeficiency Virus Type 1 (HIV-1) 100%
• Monocyte-derived Macrophages 100%
• Nuclear factor-B 100%
• Microglial Cells 100%
• RB Pathway 100%
• Chemokine CXCL8 100%
• CXCL8 71%
• Monocyte-derived Microglia 28%
• Long Terminal Repeat 21%
• AIDS/HIV 14%
• Chemokines 14%
• Human Immunodeficiency virus-1 Infection 14%
• CXCR2 14%
• CXCR1 14%
• Productive Infection 14%
• Tumor Necrosis Factor-α 7%
• Leukocytes 7%
• Central Nervous System 7%
• Interleukin-1β 7%
• Promoter Activity 7%
• Antiretroviral Therapy 7%
• Brain Tissue 7%
• Neurodegenerative Diseases 7%
• Inflammatory Cytokines 7%
• Brain-inspired 7%
• Neuropathogenesis 7%
• Nuclear Translocation 7%
• Luciferase Reporter 7%
• Supernatant 7%
• Nervous System Diseases 7%
• Blood-brain Barrier 7%
• Downstream Effects 7%
• Reporter Construct 7%
• Human Astrocytes 7%
• Viral Genome 7%
• Transient Transfection 7%
• Neutrophil Chemotaxis 7%
• Genomic Integration 7%
• U937 Cells 7%

Immunology and Microbiology

• Human Immunodeficiency Virus 1 100%
• Macrophage 100%
• Microglia 100%
• Complement Factor B 100%
• Interleukin 8 100%
• Long Terminal Repeat 18%
• Central Nervous System 12%
• Human Immunodeficiency Virus 12%
• Chemokine 12%
• Interleukin 8 Receptor, Beta 12%
• Interleukin 8 Receptor, Alpha 12%
• Leukocyte 6%
• Neutrophil 6%
• Promoter Region 6%
• Interleukin 1 6%
• Astrocyte 6%
• Cytokine 6%
• Upregulation 6%
• Tumor Necrosis Factor 6%
• Blood Brain Barrier 6%
• Supernatant 6%
• Proinflammatory Cytokine 6%
• Chemoattractant 6%
• Brain Tissue 6%
• Transient Transfection 6%
• Virus Genome 6%