Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study

for the HABLE Study Team

doi:10.1002/alz.12404

Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study

for the HABLE Study Team

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Introduction: No large-scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations. Methods: Baseline data were analyzed among n = 890 Mexican Americans and n = 813 non-Hispanic Whites from the multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Plasma NfL was measured on the Simoa platform. Results: In unadjusted models, NfL was significantly associated with age (P <.001), hypertension (P <.001), dyslipidemia (P =.02), and diabetes (P <.001). Covarying for age and sex, NfL was associated with neurodegeneration (P <.001) and global amyloid burden levels (P =.02) in a subset with available data. NfL levels were significantly associated with diagnostic groups (Normal Cognition [NC], mild cognitive impairment [MCI], Dementia; P <.001); however, there was no cut-score that yielded acceptable diagnostic accuracy. NfL levels produced a sensitivity of 0.60 and specificity of 0.78 with negative predictive value of 89% for detecting amyloid positivity. Discussion: Plasma NfL levels are significantly impacted by age and medical co-morbidities that are common among older adults, which complicate its utility as a diagnostic biomarker.

Original language	English
Pages (from-to)	240-250
Number of pages	11
Journal	Alzheimer's and Dementia
Volume	18
Issue number	2
DOIs	https://doi.org/10.1002/alz.12404
State	Published - Feb 2022

Keywords

Alzheimer's disease
Hispanic
Mexican American
diversity
plasma NfL

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10.1002/alz.12404

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@article{5544374f94ee4223b3d3bdf6ea4e4c5c,

title = "Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study",

abstract = "Introduction: No large-scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations. Methods: Baseline data were analyzed among n = 890 Mexican Americans and n = 813 non-Hispanic Whites from the multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Plasma NfL was measured on the Simoa platform. Results: In unadjusted models, NfL was significantly associated with age (P <.001), hypertension (P <.001), dyslipidemia (P =.02), and diabetes (P <.001). Covarying for age and sex, NfL was associated with neurodegeneration (P <.001) and global amyloid burden levels (P =.02) in a subset with available data. NfL levels were significantly associated with diagnostic groups (Normal Cognition [NC], mild cognitive impairment [MCI], Dementia; P <.001); however, there was no cut-score that yielded acceptable diagnostic accuracy. NfL levels produced a sensitivity of 0.60 and specificity of 0.78 with negative predictive value of 89% for detecting amyloid positivity. Discussion: Plasma NfL levels are significantly impacted by age and medical co-morbidities that are common among older adults, which complicate its utility as a diagnostic biomarker.",

keywords = "Alzheimer's disease, Hispanic, Mexican American, diversity, plasma NfL",

author = "{for the HABLE Study Team} and Sid O'Bryant and Melissa Petersen and James Hall and Leigh Johnson and Kristine Yaffe and Meredith Braskie and Toga, {Arthur W.} and Rissman, {Robert A.}",

note = "Funding Information: Research reported here was supported by the National Institute on Aging of the National Institutes of Health under Award Numbers R01AG054073 and R01AG058533. This work was also supported in part by NIH/NIBIB award P41‐EB015992. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The research team also thanks the local Fort Worth community and participants of the HABLE study. Publisher Copyright: {\textcopyright} 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2022",

month = feb,

doi = "10.1002/alz.12404",

language = "English",

volume = "18",

pages = "240--250",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Characterizing plasma NfL in a community-dwelling multi-ethnic cohort

T2 - Results from the HABLE study

AU - for the HABLE Study Team

AU - O'Bryant, Sid

AU - Petersen, Melissa

AU - Hall, James

AU - Johnson, Leigh

AU - Yaffe, Kristine

AU - Braskie, Meredith

AU - Toga, Arthur W.

AU - Rissman, Robert A.

N1 - Funding Information: Research reported here was supported by the National Institute on Aging of the National Institutes of Health under Award Numbers R01AG054073 and R01AG058533. This work was also supported in part by NIH/NIBIB award P41‐EB015992. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The research team also thanks the local Fort Worth community and participants of the HABLE study. Publisher Copyright: © 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

PY - 2022/2

Y1 - 2022/2

N2 - Introduction: No large-scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations. Methods: Baseline data were analyzed among n = 890 Mexican Americans and n = 813 non-Hispanic Whites from the multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Plasma NfL was measured on the Simoa platform. Results: In unadjusted models, NfL was significantly associated with age (P <.001), hypertension (P <.001), dyslipidemia (P =.02), and diabetes (P <.001). Covarying for age and sex, NfL was associated with neurodegeneration (P <.001) and global amyloid burden levels (P =.02) in a subset with available data. NfL levels were significantly associated with diagnostic groups (Normal Cognition [NC], mild cognitive impairment [MCI], Dementia; P <.001); however, there was no cut-score that yielded acceptable diagnostic accuracy. NfL levels produced a sensitivity of 0.60 and specificity of 0.78 with negative predictive value of 89% for detecting amyloid positivity. Discussion: Plasma NfL levels are significantly impacted by age and medical co-morbidities that are common among older adults, which complicate its utility as a diagnostic biomarker.

AB - Introduction: No large-scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations. Methods: Baseline data were analyzed among n = 890 Mexican Americans and n = 813 non-Hispanic Whites from the multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Plasma NfL was measured on the Simoa platform. Results: In unadjusted models, NfL was significantly associated with age (P <.001), hypertension (P <.001), dyslipidemia (P =.02), and diabetes (P <.001). Covarying for age and sex, NfL was associated with neurodegeneration (P <.001) and global amyloid burden levels (P =.02) in a subset with available data. NfL levels were significantly associated with diagnostic groups (Normal Cognition [NC], mild cognitive impairment [MCI], Dementia; P <.001); however, there was no cut-score that yielded acceptable diagnostic accuracy. NfL levels produced a sensitivity of 0.60 and specificity of 0.78 with negative predictive value of 89% for detecting amyloid positivity. Discussion: Plasma NfL levels are significantly impacted by age and medical co-morbidities that are common among older adults, which complicate its utility as a diagnostic biomarker.

KW - Alzheimer's disease

KW - Hispanic

KW - Mexican American

KW - diversity

KW - plasma NfL

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U2 - 10.1002/alz.12404

DO - 10.1002/alz.12404

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C2 - 34310015

AN - SCOPUS:85111258334

SN - 1552-5260

VL - 18

SP - 240

EP - 250

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 2

ER -

Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study

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