TY - JOUR
T1 - Characterization of Mild Cognitive Impairment and Dementia among Community-Dwelling Mexican Americans and Non-Hispanic Whites
AU - HABS-HD Study Team
AU - O'Bryant, Sid E.
AU - Petersen, Melissa
AU - Hall, James
AU - Johnson, Leigh A.
AU - Barber, Robert
AU - Phillips, Nicole
AU - Braskie, Meredith N.
AU - Yaffe, Kristine
AU - Rissman, Robert
AU - Toga, Arthur
AU - King, Kevin
AU - Borzage, Matthew
AU - Palmer, Raymond
AU - Shi, Yonggang
AU - Zhang, Fan
AU - Nandy, Rajesh
AU - McColl, Roderick
AU - Mason, David
AU - Christian, Bradley
AU - Philips, Nicole
AU - Large, Stephanie
N1 - Funding Information:
Research reported here was supported by the National Institute on Aging of the National Institutes of Health under Award Numbers R01AG054073 and R01AG058533. This work was also supported in part by NIH/NIBIB award P41-EB015922. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The sponsor had no role in study design, data collection, data analysis/interpretation or generation of manuscripts. The research team also thanks the local Fort Worth community and the participants of the HABS-HD study.
Publisher Copyright:
© 2022 - IOS Press. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Background: Despite tremendous advancements in the field, our understanding of mild cognitive impairment (MCI) and Alzheimer's disease (AD) among Mexican Americans remains limited. Objective: The aim of this study was to characterize MCI and dementia among Mexican Americans and non-Hispanic whites. Methods: Baseline data were analyzed from n=1,705 (n=890 Mexican American; n=815 non-Hispanic white) participants enrolled in the Health and Aging Brain Study-Health Disparities (HABS-HD). Results: Among Mexican Americans, age (OR=1.07), depression (OR=1.09), and MRI-based neurodegeneration (OR=0.01) were associated with dementia, but none of these factors were associated with MCI. Among non-Hispanic whites, male gender (OR=0.33), neighborhood deprivation (OR=1.34), depression (OR=1.09), and MRI-based neurodegeneration (OR=0.03) were associated with MCI, while depression (OR=1.09) and APOE ϵ4 genotype (OR=4.38) were associated with dementia. Conclusion: Findings from this study revealed that the demographic, clinical, sociocultural and biomarker characteristics of MCI and dementia are different among Mexican Americans as compared to non-Hispanic whites.
AB - Background: Despite tremendous advancements in the field, our understanding of mild cognitive impairment (MCI) and Alzheimer's disease (AD) among Mexican Americans remains limited. Objective: The aim of this study was to characterize MCI and dementia among Mexican Americans and non-Hispanic whites. Methods: Baseline data were analyzed from n=1,705 (n=890 Mexican American; n=815 non-Hispanic white) participants enrolled in the Health and Aging Brain Study-Health Disparities (HABS-HD). Results: Among Mexican Americans, age (OR=1.07), depression (OR=1.09), and MRI-based neurodegeneration (OR=0.01) were associated with dementia, but none of these factors were associated with MCI. Among non-Hispanic whites, male gender (OR=0.33), neighborhood deprivation (OR=1.34), depression (OR=1.09), and MRI-based neurodegeneration (OR=0.03) were associated with MCI, while depression (OR=1.09) and APOE ϵ4 genotype (OR=4.38) were associated with dementia. Conclusion: Findings from this study revealed that the demographic, clinical, sociocultural and biomarker characteristics of MCI and dementia are different among Mexican Americans as compared to non-Hispanic whites.
KW - Alzheimer's disease
KW - Hispanic
KW - health disparities
KW - mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85141938865&partnerID=8YFLogxK
U2 - 10.3233/JAD-220300
DO - 10.3233/JAD-220300
M3 - Article
C2 - 36189588
AN - SCOPUS:85141938865
SN - 1387-2877
VL - 90
SP - 905
EP - 915
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 2
ER -