Characterization of Macromolecules by Electrospray Ionization Mass Spectrometry

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13 Citations (Scopus)

Abstract

Application of electrospray ionization (ESI) mass spectrometry (MS) to the analysis of oligomers and polymers is reviewed through several representative examples. The benefits and limitations of the technique are discussed considering the molecular weight and complexity (polydispersity) of the analyte. Recent results demonstrating the advantage of using hyphenated techniques such as size exclusion chromatography (SEC) coupled with ESI-MS are highlighted.

Original languageEnglish
Pages (from-to)379-391
Number of pages13
JournalInternational Journal of Polymer Analysis and Characterization
Volume6
Issue number3-4
DOIs
StatePublished - 1 Jan 2001

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Electrospray ionization
Macromolecules
Mass spectrometry
Size exclusion chromatography
Polydispersity
Oligomers
Polymers
Molecular weight

Keywords

  • 2-Hydroxypropyl-β-cyclodextrin
  • Electrospray ionization
  • Mass spectrometry
  • Octylphenoxypoly(ethoxy)ethanol
  • Size-exclusion chromatography

Cite this

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title = "Characterization of Macromolecules by Electrospray Ionization Mass Spectrometry",
abstract = "Application of electrospray ionization (ESI) mass spectrometry (MS) to the analysis of oligomers and polymers is reviewed through several representative examples. The benefits and limitations of the technique are discussed considering the molecular weight and complexity (polydispersity) of the analyte. Recent results demonstrating the advantage of using hyphenated techniques such as size exclusion chromatography (SEC) coupled with ESI-MS are highlighted.",
keywords = "2-Hydroxypropyl-β-cyclodextrin, Electrospray ionization, Mass spectrometry, Octylphenoxypoly(ethoxy)ethanol, Size-exclusion chromatography",
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AB - Application of electrospray ionization (ESI) mass spectrometry (MS) to the analysis of oligomers and polymers is reviewed through several representative examples. The benefits and limitations of the technique are discussed considering the molecular weight and complexity (polydispersity) of the analyte. Recent results demonstrating the advantage of using hyphenated techniques such as size exclusion chromatography (SEC) coupled with ESI-MS are highlighted.

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KW - Electrospray ionization

KW - Mass spectrometry

KW - Octylphenoxypoly(ethoxy)ethanol

KW - Size-exclusion chromatography

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