Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama

Alcibiades E. Villarreal, Shantal Grajales, Sidney O'Bryant, Melissa Edwards, Lineth López, Astevia Montalván, Gabrielle B. Britton

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Research on age-related cognitive impairment is scarce in Central America. We report factors associated with cognitive impairment among a sample of older adults in Panama diagnosed with Alzheimer's disease (AD, n=31), mild cognitive impairment (MCI, n=43), or no cognitive impairment (controls, n=185). Apolipoprotein E (ApoE) genotype was assessed in a subset of cases (n=135). Age (OR=2.53, 95% CI=1.03-6.17) and ApoE ϵ4 (OR=5.14, 95% CI=2.11-12.52) were significantly related to cognitive impairment (AD/MCI combined). Results underscore the potential of genetic screening in Panama for identifying those at risk of dementia.

Original languageEnglish
Pages (from-to)897-901
Number of pages5
JournalJournal of Alzheimer's Disease
Volume54
Issue number3
DOIs
StatePublished - 1 Jan 2016

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Panama
Alzheimer Disease
Apolipoprotein E4
Central America
Genetic Testing
Apolipoproteins E
Dementia
Genotype
Cognitive Dysfunction
Research

Keywords

  • Aging
  • Alzheimer's disease
  • apolipoprotein E
  • cognition
  • dementia
  • Latin America
  • mild cognitive impairment

Cite this

Villarreal, A. E., Grajales, S., O'Bryant, S., Edwards, M., López, L., Montalván, A., & Britton, G. B. (2016). Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama. Journal of Alzheimer's Disease, 54(3), 897-901. https://doi.org/10.3233/JAD-160402
Villarreal, Alcibiades E. ; Grajales, Shantal ; O'Bryant, Sidney ; Edwards, Melissa ; López, Lineth ; Montalván, Astevia ; Britton, Gabrielle B. / Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama. In: Journal of Alzheimer's Disease. 2016 ; Vol. 54, No. 3. pp. 897-901.
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Villarreal, AE, Grajales, S, O'Bryant, S, Edwards, M, López, L, Montalván, A & Britton, GB 2016, 'Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama', Journal of Alzheimer's Disease, vol. 54, no. 3, pp. 897-901. https://doi.org/10.3233/JAD-160402

Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama. / Villarreal, Alcibiades E.; Grajales, Shantal; O'Bryant, Sidney; Edwards, Melissa; López, Lineth; Montalván, Astevia; Britton, Gabrielle B.

In: Journal of Alzheimer's Disease, Vol. 54, No. 3, 01.01.2016, p. 897-901.

Research output: Contribution to journalArticle

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