Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama

Alcibiades E. Villarreal, Shantal Grajales, Sid E. O'Bryant, Melissa Edwards, Lineth López, Astevia Montalván, Gabrielle B. Britton

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2 Scopus citations

Abstract

Research on age-related cognitive impairment is scarce in Central America. We report factors associated with cognitive impairment among a sample of older adults in Panama diagnosed with Alzheimer's disease (AD, n=31), mild cognitive impairment (MCI, n=43), or no cognitive impairment (controls, n=185). Apolipoprotein E (ApoE) genotype was assessed in a subset of cases (n=135). Age (OR=2.53, 95% CI=1.03-6.17) and ApoE ϵ4 (OR=5.14, 95% CI=2.11-12.52) were significantly related to cognitive impairment (AD/MCI combined). Results underscore the potential of genetic screening in Panama for identifying those at risk of dementia.

Original languageEnglish
Pages (from-to)897-901
Number of pages5
JournalJournal of Alzheimer's Disease
Volume54
Issue number3
DOIs
StatePublished - 1 Jan 2016

Keywords

  • Aging
  • Alzheimer's disease
  • Latin America
  • apolipoprotein E
  • cognition
  • dementia
  • mild cognitive impairment

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    Villarreal, A. E., Grajales, S., O'Bryant, S. E., Edwards, M., López, L., Montalván, A., & Britton, G. B. (2016). Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama. Journal of Alzheimer's Disease, 54(3), 897-901. https://doi.org/10.3233/JAD-160402