Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama

Alcibiades E. Villarreal; Shantal Grajales; Sid E. O'Bryant; Melissa Edwards; Lineth López; Astevia Montalván; Gabrielle B. Britton

doi:10.3233/JAD-160402

Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama

Alcibiades E. Villarreal, Shantal Grajales, Sid E. O'Bryant, Melissa Edwards, Lineth López, Astevia Montalván, Gabrielle B. Britton

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4 Scopus citations

Abstract

Research on age-related cognitive impairment is scarce in Central America. We report factors associated with cognitive impairment among a sample of older adults in Panama diagnosed with Alzheimer's disease (AD, n=31), mild cognitive impairment (MCI, n=43), or no cognitive impairment (controls, n=185). Apolipoprotein E (ApoE) genotype was assessed in a subset of cases (n=135). Age (OR=2.53, 95% CI=1.03-6.17) and ApoE ϵ4 (OR=5.14, 95% CI=2.11-12.52) were significantly related to cognitive impairment (AD/MCI combined). Results underscore the potential of genetic screening in Panama for identifying those at risk of dementia.

Original language	English
Pages (from-to)	897-901
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	54
Issue number	3
DOIs	https://doi.org/10.3233/JAD-160402
State	Published - 1 Jan 2016

Keywords

Aging
Alzheimer's disease
Latin America
apolipoprotein E
cognition
dementia
mild cognitive impairment

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10.3233/JAD-160402

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abstract = "Research on age-related cognitive impairment is scarce in Central America. We report factors associated with cognitive impairment among a sample of older adults in Panama diagnosed with Alzheimer's disease (AD, n=31), mild cognitive impairment (MCI, n=43), or no cognitive impairment (controls, n=185). Apolipoprotein E (ApoE) genotype was assessed in a subset of cases (n=135). Age (OR=2.53, 95% CI=1.03-6.17) and ApoE ϵ4 (OR=5.14, 95% CI=2.11-12.52) were significantly related to cognitive impairment (AD/MCI combined). Results underscore the potential of genetic screening in Panama for identifying those at risk of dementia.",

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AU - López, Lineth

AU - Montalván, Astevia

AU - Britton, Gabrielle B.

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Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama

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Keywords

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