TY - JOUR
T1 - Characterization of a new composite PMMA-HA/Brushite bone cement for spinal augmentation
AU - Aghyarian, Shant
AU - Rodriguez, Lucas C.
AU - Chari, Jonathan
AU - Bentley, Elizabeth
AU - Kosmopoulos, Victor
AU - Lieberman, Isador H.
AU - Rodrigues, Danieli C.
N1 - Funding Information:
This study was partially funded by UT Transform Award mechanism (project ID 1436).
Publisher Copyright:
© The Author(s) 2014.
PY - 2014/11/11
Y1 - 2014/11/11
N2 - Calcium phosphate fillers have been shown to increase cement osteoconductivity, but have caused drawbacks in cement properties. Hydroxyapatite and Brushite were introduced in an acrylic two-solution cement at varying concentrations. Novel composite bone cements were developed and characterized using rheology, injectability, and mechanical tests. It was hypothesized that the ample swelling time allowed by the premixed two-solution cement would enable thorough dispersion of the additives in the solutions, resulting in no detrimental effects after polymerization. The addition of Hydroxyapatite and Brushite both caused an increase in cement viscosity; however, these cements exhibited high shear-thinning, which facilitated injection. In gel point studies, the composite cements showed no detectable change in gel point time compared to an all-acrylic control cement. Hydroxyapatite and Brushite composite cements were observed to have high mechanical strengths even at high loads of calcium phosphate fillers. These cements showed an average compressive strength of 85 MPa and flexural strength of 65 MPa. A calcium phosphate-containing cement exhibiting a combination of high viscosity, pseudoplasticity and high mechanical strength can provide the essential bioactivity factor for osseointegration without sacrificing load-bearing capability.
AB - Calcium phosphate fillers have been shown to increase cement osteoconductivity, but have caused drawbacks in cement properties. Hydroxyapatite and Brushite were introduced in an acrylic two-solution cement at varying concentrations. Novel composite bone cements were developed and characterized using rheology, injectability, and mechanical tests. It was hypothesized that the ample swelling time allowed by the premixed two-solution cement would enable thorough dispersion of the additives in the solutions, resulting in no detrimental effects after polymerization. The addition of Hydroxyapatite and Brushite both caused an increase in cement viscosity; however, these cements exhibited high shear-thinning, which facilitated injection. In gel point studies, the composite cements showed no detectable change in gel point time compared to an all-acrylic control cement. Hydroxyapatite and Brushite composite cements were observed to have high mechanical strengths even at high loads of calcium phosphate fillers. These cements showed an average compressive strength of 85 MPa and flexural strength of 65 MPa. A calcium phosphate-containing cement exhibiting a combination of high viscosity, pseudoplasticity and high mechanical strength can provide the essential bioactivity factor for osseointegration without sacrificing load-bearing capability.
KW - Composite bone cement
KW - bone cement
KW - calcium phosphate
KW - poly-methyl methacrylate
KW - spine
KW - vertebral compression fracture
KW - vertebroplasty
UR - http://www.scopus.com/inward/record.url?scp=84908869208&partnerID=8YFLogxK
U2 - 10.1177/0885328214544770
DO - 10.1177/0885328214544770
M3 - Article
C2 - 25085810
AN - SCOPUS:84908869208
SN - 0885-3282
VL - 29
SP - 688
EP - 698
JO - Journal of Biomaterials Applications
JF - Journal of Biomaterials Applications
IS - 5
ER -