Characterization of a new composite PMMA-HA/Brushite bone cement for spinal augmentation

Shant Aghyarian, Lucas C. Rodriguez, Jonathan Chari, Elizabeth Bentley, Victor Kosmopoulos, Isador H. Lieberman, Danieli C. Rodrigues

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Calcium phosphate fillers have been shown to increase cement osteoconductivity, but have caused drawbacks in cement properties. Hydroxyapatite and Brushite were introduced in an acrylic two-solution cement at varying concentrations. Novel composite bone cements were developed and characterized using rheology, injectability, and mechanical tests. It was hypothesized that the ample swelling time allowed by the premixed two-solution cement would enable thorough dispersion of the additives in the solutions, resulting in no detrimental effects after polymerization. The addition of Hydroxyapatite and Brushite both caused an increase in cement viscosity; however, these cements exhibited high shear-thinning, which facilitated injection. In gel point studies, the composite cements showed no detectable change in gel point time compared to an all-acrylic control cement. Hydroxyapatite and Brushite composite cements were observed to have high mechanical strengths even at high loads of calcium phosphate fillers. These cements showed an average compressive strength of 85 MPa and flexural strength of 65 MPa. A calcium phosphate-containing cement exhibiting a combination of high viscosity, pseudoplasticity and high mechanical strength can provide the essential bioactivity factor for osseointegration without sacrificing load-bearing capability.

Original languageEnglish
Pages (from-to)688-698
Number of pages11
JournalJournal of Biomaterials Applications
Volume29
Issue number5
DOIs
StatePublished - 11 Nov 2014

Fingerprint

Bone cement
Bone Cements
Polymethyl Methacrylate
Durapatite
Cements
Viscosity
Composite materials
Calcium phosphate
Gels
Hydroxyapatite
Compressive Strength
Osseointegration
Rheology
Weight-Bearing
Polymerization
Acrylics
Strength of materials
Fillers
Bearings (structural)
Injections

Keywords

  • Composite bone cement
  • bone cement
  • calcium phosphate
  • poly-methyl methacrylate
  • spine
  • vertebral compression fracture
  • vertebroplasty

Cite this

Aghyarian, S., Rodriguez, L. C., Chari, J., Bentley, E., Kosmopoulos, V., Lieberman, I. H., & Rodrigues, D. C. (2014). Characterization of a new composite PMMA-HA/Brushite bone cement for spinal augmentation. Journal of Biomaterials Applications, 29(5), 688-698. https://doi.org/10.1177/0885328214544770
Aghyarian, Shant ; Rodriguez, Lucas C. ; Chari, Jonathan ; Bentley, Elizabeth ; Kosmopoulos, Victor ; Lieberman, Isador H. ; Rodrigues, Danieli C. / Characterization of a new composite PMMA-HA/Brushite bone cement for spinal augmentation. In: Journal of Biomaterials Applications. 2014 ; Vol. 29, No. 5. pp. 688-698.
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Aghyarian, S, Rodriguez, LC, Chari, J, Bentley, E, Kosmopoulos, V, Lieberman, IH & Rodrigues, DC 2014, 'Characterization of a new composite PMMA-HA/Brushite bone cement for spinal augmentation', Journal of Biomaterials Applications, vol. 29, no. 5, pp. 688-698. https://doi.org/10.1177/0885328214544770

Characterization of a new composite PMMA-HA/Brushite bone cement for spinal augmentation. / Aghyarian, Shant; Rodriguez, Lucas C.; Chari, Jonathan; Bentley, Elizabeth; Kosmopoulos, Victor; Lieberman, Isador H.; Rodrigues, Danieli C.

In: Journal of Biomaterials Applications, Vol. 29, No. 5, 11.11.2014, p. 688-698.

Research output: Contribution to journalArticle

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Aghyarian S, Rodriguez LC, Chari J, Bentley E, Kosmopoulos V, Lieberman IH et al. Characterization of a new composite PMMA-HA/Brushite bone cement for spinal augmentation. Journal of Biomaterials Applications. 2014 Nov 11;29(5):688-698. https://doi.org/10.1177/0885328214544770