Changes in serotonin contents in brain affect metabolic heat production of rabbits in cold

M. T. Lin, I. H. Pang, S. I. Chern, W. Y. Chia

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Abstract

Elevating serotonin (5-HT) contents in brain with 5-hydroxytryptophan (5-HTP) reduced rectal temperature (Tre) in rabbits after peripheral decarboxylase inhibition with the aromatic-L-amino-aicd decarboxylase inhibitor R04-4602 at two ambient temperatures (Ta), 2 and 22°C. The hypothermia was brought about by both an increase in respiratory evaporative heat loss (Eres) and a decrease in metabolic rate (MR) in the cold. At a Ta of 22°C, the hypothermia was achieved solely due to an increase in heat loss. Depleting brain contents of 5-HT with intraventricular, 5,7-dihydroxytryptamine (5,7-DHT) produced an increased Eres and ear blood flow even at Ta of 2°C. Also, MR increased at all but the Ta of 32°C. However, depleting the central and peripheral contents of 5-HT with p-chlorophenylalanine (pCPA) produced lower MR accompanied by lower Eres in the cold compared to the untreated control. Both groups of pCPA-treated and 5,7-DHT-treated animals maintained their Tre within normal limits. The data suggest that changes in 5-HT content in brain affects the MR of rabbits in the cold. Elevating brain content of 5-HT tends to depress the MR response to cold, while depleting brain content of 5-HT tends to enhance the MR response to cold.

Original languageEnglish
Pages (from-to)R41-R47
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume4
Issue number1
StatePublished - 1 Jan 1978

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Thermogenesis
Serotonin
Rabbits
Brain
Temperature
5,7-Dihydroxytryptamine
Fenclonine
Carboxy-Lyases
Hypothermia
Hot Temperature
5-Hydroxytryptophan
Ear

Cite this

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title = "Changes in serotonin contents in brain affect metabolic heat production of rabbits in cold",
abstract = "Elevating serotonin (5-HT) contents in brain with 5-hydroxytryptophan (5-HTP) reduced rectal temperature (Tre) in rabbits after peripheral decarboxylase inhibition with the aromatic-L-amino-aicd decarboxylase inhibitor R04-4602 at two ambient temperatures (Ta), 2 and 22°C. The hypothermia was brought about by both an increase in respiratory evaporative heat loss (Eres) and a decrease in metabolic rate (MR) in the cold. At a Ta of 22°C, the hypothermia was achieved solely due to an increase in heat loss. Depleting brain contents of 5-HT with intraventricular, 5,7-dihydroxytryptamine (5,7-DHT) produced an increased Eres and ear blood flow even at Ta of 2°C. Also, MR increased at all but the Ta of 32°C. However, depleting the central and peripheral contents of 5-HT with p-chlorophenylalanine (pCPA) produced lower MR accompanied by lower Eres in the cold compared to the untreated control. Both groups of pCPA-treated and 5,7-DHT-treated animals maintained their Tre within normal limits. The data suggest that changes in 5-HT content in brain affects the MR of rabbits in the cold. Elevating brain content of 5-HT tends to depress the MR response to cold, while depleting brain content of 5-HT tends to enhance the MR response to cold.",
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Changes in serotonin contents in brain affect metabolic heat production of rabbits in cold. / Lin, M. T.; Pang, I. H.; Chern, S. I.; Chia, W. Y.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 4, No. 1, 01.01.1978, p. R41-R47.

Research output: Contribution to journalArticle

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