Changes in plasma apo B, apo E, apo A-1, and apo A-IV concentrations in dogs consuming different atherogenic diets

George W. Melchior, Ladislav Dory, Paul S. Roheim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To define the relationship between apoprotein levels and plasma cholesterol concentration in dogs, we measured the cholesterol, apo B, apo E, apo A-IV, and apo A-1 levels in 6 dogs fed a synthetic diet (Diet I), and in 5 dogs fed dog chow supplemented with lard, cholesterol, bile salts, and propylthiouracil (Diet II). The diet-induced hypercholesterolemia exceeded 900 mg/dl in dogs fed Diet I and was accompanied by a 12-fold increase in apo B, a 30-fold increase in apo E, an 8-fold increase in apo A-IV, and a l2'-fold increase in apo A-1. By contrast, the hypercholesterolemia averaged 1300 mg/dl in dogs fed Diet II and was accompanied by a 12-fold increase in apo B, an 11-fold increase in apo E, a 3-fold increase in apo A-IV, and a 5-fold decrease in apo A-1 levels. When 3 of the Diet I dogs were switched to dog chow, their plasma cholesterol, apo B, and apo E levels dropped to 30% of their peak value within 7 days. The change in apo B and apo E levels was found to be highly correlated with the change in plasma cholesterol concentrations in each of the Diet I animals (r2 ranged from 0.92 to 0.99 for both apoproteins). A strong linear relationship was also observed between apo E and apo B (r2 ranged from 0.94 to 0.98), indicating that the plasma apo E to apo B ratio remained constant in these animals as the hypercholesterolemia progressed or regressed.

Original languageEnglish
Pages (from-to)47-57
Number of pages11
JournalAtherosclerosis
Volume52
Issue number1
DOIs
StatePublished - 1 Jan 1984

Fingerprint

Atherogenic Diet
Apolipoprotein A-I
Apolipoproteins B
Apolipoproteins E
Dogs
Diet
Cholesterol
Hypercholesterolemia
Apoproteins
Apolipoprotein E3
Formulated Food
Propylthiouracil
apolipoprotein A-IV
Bile Acids and Salts

Keywords

  • Apo A-I
  • Apo A-IV
  • Apo B
  • Apo E
  • Hypercholesterolemia

Cite this

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title = "Changes in plasma apo B, apo E, apo A-1, and apo A-IV concentrations in dogs consuming different atherogenic diets",
abstract = "To define the relationship between apoprotein levels and plasma cholesterol concentration in dogs, we measured the cholesterol, apo B, apo E, apo A-IV, and apo A-1 levels in 6 dogs fed a synthetic diet (Diet I), and in 5 dogs fed dog chow supplemented with lard, cholesterol, bile salts, and propylthiouracil (Diet II). The diet-induced hypercholesterolemia exceeded 900 mg/dl in dogs fed Diet I and was accompanied by a 12-fold increase in apo B, a 30-fold increase in apo E, an 8-fold increase in apo A-IV, and a l2'-fold increase in apo A-1. By contrast, the hypercholesterolemia averaged 1300 mg/dl in dogs fed Diet II and was accompanied by a 12-fold increase in apo B, an 11-fold increase in apo E, a 3-fold increase in apo A-IV, and a 5-fold decrease in apo A-1 levels. When 3 of the Diet I dogs were switched to dog chow, their plasma cholesterol, apo B, and apo E levels dropped to 30{\%} of their peak value within 7 days. The change in apo B and apo E levels was found to be highly correlated with the change in plasma cholesterol concentrations in each of the Diet I animals (r2 ranged from 0.92 to 0.99 for both apoproteins). A strong linear relationship was also observed between apo E and apo B (r2 ranged from 0.94 to 0.98), indicating that the plasma apo E to apo B ratio remained constant in these animals as the hypercholesterolemia progressed or regressed.",
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Changes in plasma apo B, apo E, apo A-1, and apo A-IV concentrations in dogs consuming different atherogenic diets. / Melchior, George W.; Dory, Ladislav; Roheim, Paul S.

In: Atherosclerosis, Vol. 52, No. 1, 01.01.1984, p. 47-57.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Changes in plasma apo B, apo E, apo A-1, and apo A-IV concentrations in dogs consuming different atherogenic diets

AU - Melchior, George W.

AU - Dory, Ladislav

AU - Roheim, Paul S.

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AB - To define the relationship between apoprotein levels and plasma cholesterol concentration in dogs, we measured the cholesterol, apo B, apo E, apo A-IV, and apo A-1 levels in 6 dogs fed a synthetic diet (Diet I), and in 5 dogs fed dog chow supplemented with lard, cholesterol, bile salts, and propylthiouracil (Diet II). The diet-induced hypercholesterolemia exceeded 900 mg/dl in dogs fed Diet I and was accompanied by a 12-fold increase in apo B, a 30-fold increase in apo E, an 8-fold increase in apo A-IV, and a l2'-fold increase in apo A-1. By contrast, the hypercholesterolemia averaged 1300 mg/dl in dogs fed Diet II and was accompanied by a 12-fold increase in apo B, an 11-fold increase in apo E, a 3-fold increase in apo A-IV, and a 5-fold decrease in apo A-1 levels. When 3 of the Diet I dogs were switched to dog chow, their plasma cholesterol, apo B, and apo E levels dropped to 30% of their peak value within 7 days. The change in apo B and apo E levels was found to be highly correlated with the change in plasma cholesterol concentrations in each of the Diet I animals (r2 ranged from 0.92 to 0.99 for both apoproteins). A strong linear relationship was also observed between apo E and apo B (r2 ranged from 0.94 to 0.98), indicating that the plasma apo E to apo B ratio remained constant in these animals as the hypercholesterolemia progressed or regressed.

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