Abstract
To study the regulation of carnitine palmitoyltransferase-I by thyroid hormone, a cDNA was obtained by PCR amplification of DNA obtained by reverse transcription of rat liver RNA. CPT-I mRNA abundance was measured in livers of hyperthyroid, euthyroid and hypothyroid rats. In hypothyroid rats, the CPT-I mRNA levels decreased 40-fold relative to that of the hyperthyroid animals. These changes paralleled alterations in enzyme activity. These data suggest that CPT-I is regulated at the transcriptonal level by thyroid hormone.
Original language | English |
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Pages (from-to) | 932-937 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 201 |
Issue number | 2 |
DOIs | |
State | Published - 15 Jun 1994 |