Changes in carnitine palmitoyltransferase-i mrna abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity

Randall L. Mynatt, Edwards A. Park, Fayanne E. Thorngate, Hriday Das, George A. Cook

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

To study the regulation of carnitine palmitoyltransferase-I by thyroid hormone, a cDNA was obtained by PCR amplification of DNA obtained by reverse transcription of rat liver RNA. CPT-I mRNA abundance was measured in livers of hyperthyroid, euthyroid and hypothyroid rats. In hypothyroid rats, the CPT-I mRNA levels decreased 40-fold relative to that of the hyperthyroid animals. These changes paralleled alterations in enzyme activity. These data suggest that CPT-I is regulated at the transcriptonal level by thyroid hormone.

Original languageEnglish
Pages (from-to)932-937
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume201
Issue number2
DOIs
StatePublished - 15 Jun 1994

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