Changes in carnitine palmitoyltransferase-i mrna abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity

Randall L. Mynatt; Edwards A. Park; Fayanne E. Thorngate; Hriday K. Das; George A. Cook

doi:10.1006/bbrc.1994.1791

Changes in carnitine palmitoyltransferase-i mrna abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity

Randall L. Mynatt, Edwards A. Park, Fayanne E. Thorngate, Hriday K. Das, George A. Cook

Research output: Contribution to journal › Article › peer-review

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Abstract

To study the regulation of carnitine palmitoyltransferase-I by thyroid hormone, a cDNA was obtained by PCR amplification of DNA obtained by reverse transcription of rat liver RNA. CPT-I mRNA abundance was measured in livers of hyperthyroid, euthyroid and hypothyroid rats. In hypothyroid rats, the CPT-I mRNA levels decreased 40-fold relative to that of the hyperthyroid animals. These changes paralleled alterations in enzyme activity. These data suggest that CPT-I is regulated at the transcriptonal level by thyroid hormone.

Original language	English
Pages (from-to)	932-937
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	201
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1994.1791
State	Published - 15 Jun 1994

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10.1006/bbrc.1994.1791

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title = "Changes in carnitine palmitoyltransferase-i mrna abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity",

abstract = "To study the regulation of carnitine palmitoyltransferase-I by thyroid hormone, a cDNA was obtained by PCR amplification of DNA obtained by reverse transcription of rat liver RNA. CPT-I mRNA abundance was measured in livers of hyperthyroid, euthyroid and hypothyroid rats. In hypothyroid rats, the CPT-I mRNA levels decreased 40-fold relative to that of the hyperthyroid animals. These changes paralleled alterations in enzyme activity. These data suggest that CPT-I is regulated at the transcriptonal level by thyroid hormone.",

author = "Mynatt, {Randall L.} and Park, {Edwards A.} and Thorngate, {Fayanne E.} and Das, {Hriday K.} and Cook, {George A.}",

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Changes in carnitine palmitoyltransferase-i mrna abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity. / Mynatt, Randall L.; Park, Edwards A.; Thorngate, Fayanne E. et al.

In: Biochemical and Biophysical Research Communications, Vol. 201, No. 2, 15.06.1994, p. 932-937.

Research output: Contribution to journal › Article › peer-review

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AU - Mynatt, Randall L.

AU - Park, Edwards A.

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AU - Das, Hriday K.

AU - Cook, George A.

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AB - To study the regulation of carnitine palmitoyltransferase-I by thyroid hormone, a cDNA was obtained by PCR amplification of DNA obtained by reverse transcription of rat liver RNA. CPT-I mRNA abundance was measured in livers of hyperthyroid, euthyroid and hypothyroid rats. In hypothyroid rats, the CPT-I mRNA levels decreased 40-fold relative to that of the hyperthyroid animals. These changes paralleled alterations in enzyme activity. These data suggest that CPT-I is regulated at the transcriptonal level by thyroid hormone.

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Changes in carnitine palmitoyltransferase-i mrna abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity

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