Cerebral small vessel disease and Alzheimer’s disease

Zhiyou Cai, Chuanling Wang, Wenbo He, Hanjun Tu, Zhengang Tang, Ming Xiao, Liang Jun Yan

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations


Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and capillaries of the brain. CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger’s disease, and cerebral microbleeds. CSVD is an important cerebral microvascular pathogenesis as it is the cause of 20% of strokes worldwide and the most common cause of cognitive impairment and dementia, including vascular dementia and Alzheimer’s disease (AD). It has been well identified that CSVD contributes to the occurrence of AD. It seems that the treatment and prevention for cerebrovascular diseases with statins have such a role in the same function for AD. So far, there is no strong evidence-based medicine to support the idea, although increasing basic studies supported the fact that the treatment and prevention for cerebrovascular diseases will benefit AD. Furthermore, there is still lack of evidence in clinical application involved in specific drugs to benefit both AD and CSVD.

Original languageEnglish
Article numberA196
Pages (from-to)1695-1704
Number of pages10
JournalClinical interventions in aging
StatePublished - 2015


  • Cerebral microbleeds
  • Cerebrovascular diseases
  • Dementia
  • Lacunar infarct
  • Leukoaraiosis


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