Catabolite repression of Escherichia coli biofilm formation

Debra W. Jackson, Jerry W. Simecka, Tony Romeo

Research output: Contribution to journalArticlepeer-review

142 Scopus citations


Biofilm formation was repressed by glucose in several species of Enterobacteriaceae. In Escherichia coli, this effect was mediated at least in part by cyclic AMP (cAMP)-cAMP receptor protein. A temporal role for cAMP in biofilm development was indicated by the finding that glucose addition after ∼24 h failed to repress and generally activated biofilm formation.

Original languageEnglish
Pages (from-to)3406-3410
Number of pages5
JournalJournal of Bacteriology
Issue number12
StatePublished - 2002


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