Ca2+-sensitive transcriptional regulation: Direct DNA interaction by DREAM

Sherry Sours-Brothers, Rong Ma, Peter Koulen

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Calcium is a major regulator of cell function, acting as a second messenger to relay signals from the cell surface to other parts of the cell. It plays an integral role in contraction of muscle cells and it regulates cell growth and proliferation, as well as cell death (1). The present review will discuss how Ca2+ mediates these functions through the regulation of gene expression. This can be accomplished by Ca2+-sensitive protein kinases as well as phosphatases which activate transcription factors. It can also be mediated by direct interaction of Ca2+-sensitive proteins with regulatory elements within the DNA sequence itself. Special attention will be given to recent advances in research in the down-stream regulatory element (DRE) and its Ca2+-sensitive modulator DREAM (downstream regulatory element antagonist modulator; also named calsenilin or K+ channel interacting protein 3 (KChIP3)) (2).

Original languageEnglish
Pages (from-to)1851-1856
Number of pages6
JournalFrontiers in Bioscience
Volume14
Issue number5
DOIs
StatePublished - 1 Jan 2009

Fingerprint

Kv Channel-Interacting Proteins
DNA sequences
DNA
Cell proliferation
Cell growth
Second Messenger Systems
Cell death
Phosphoric Monoester Hydrolases
Gene expression
Protein Kinases
Modulators
Muscle
Proteins
Transcription Factors
Phosphoprotein Phosphatases
Cells
Gene Expression Regulation
Calcium
Muscle Cells
Cell Death

Keywords

  • Calcium
  • Downstream regulatory element
  • Downstream regulatory element antagonistic modulator
  • Review
  • Transcription

Cite this

Sours-Brothers, Sherry ; Ma, Rong ; Koulen, Peter. / Ca2+-sensitive transcriptional regulation : Direct DNA interaction by DREAM. In: Frontiers in Bioscience. 2009 ; Vol. 14, No. 5. pp. 1851-1856.
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Ca2+-sensitive transcriptional regulation : Direct DNA interaction by DREAM. / Sours-Brothers, Sherry; Ma, Rong; Koulen, Peter.

In: Frontiers in Bioscience, Vol. 14, No. 5, 01.01.2009, p. 1851-1856.

Research output: Contribution to journalReview article

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