Carotid baroreflex control of leg vasculature in exercising and non-exercising skeletal muscle in humans

David Melvin Keller, Paul J. Fadel, Shigehiko Ogoh, Robert Matthews Brothers, Megan Hawkins, Albert Yurvati, Peter B. Raven

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Abstract

Carotid baroreflex (CBR) function was examined in five men and three women (25 ± 1 years) using the variable-pressure neck collar technique at rest and during dynamic, one-legged knee extension exercise at 7 W and 25 W. The CBR exhibited control of leg vascular conductance (LVC) at rest and during exercise in both an exercising leg (EL) and a non-exercising leg (NEL) across a wide range of pressures from +40 Torr neck pressure (NP) to -80 Torr neck suction (NS). Specifically, increases in LVC (% change) in response to NS were no different across -20 to -80 Torr in either EL or NEL compared to rest, P > 0.05. However, CBR-mediated decreases in percentage LVC in response to NP were attenuated in EL at both 7 W (16 ± 1%) and 25 W (12 ± 1%) compared to rest (40 ± 3%; P < 0.05) as well as compared to responses in the NEL (36 ± 6% at 7 W and 36 ± 7% at 25 W; P < 0.05). This decrease in vascular responsiveness in EL was associated with a reduction in the gain of the percentage muscle sympathetic nerve activity (%MSNA)-%LVC relationship compared to rest (P < 0.05). Collectively, these data indicate that, despite a clear attenuation of the vascular response to MSNA in the exercising leg, CBR-mediated changes in mean arterial pressure were no different between rest and exercise.

Original languageEnglish
Pages (from-to)283-293
Number of pages11
JournalJournal of Physiology
Volume561
Issue number1
DOIs
StatePublished - 15 Nov 2004

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Baroreflex
Leg
Skeletal Muscle
Blood Vessels
Neck
Pressure
Suction
Exercise
Knee
Arterial Pressure

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Keller, David Melvin ; Fadel, Paul J. ; Ogoh, Shigehiko ; Brothers, Robert Matthews ; Hawkins, Megan ; Yurvati, Albert ; Raven, Peter B. / Carotid baroreflex control of leg vasculature in exercising and non-exercising skeletal muscle in humans. In: Journal of Physiology. 2004 ; Vol. 561, No. 1. pp. 283-293.
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abstract = "Carotid baroreflex (CBR) function was examined in five men and three women (25 ± 1 years) using the variable-pressure neck collar technique at rest and during dynamic, one-legged knee extension exercise at 7 W and 25 W. The CBR exhibited control of leg vascular conductance (LVC) at rest and during exercise in both an exercising leg (EL) and a non-exercising leg (NEL) across a wide range of pressures from +40 Torr neck pressure (NP) to -80 Torr neck suction (NS). Specifically, increases in LVC ({\%} change) in response to NS were no different across -20 to -80 Torr in either EL or NEL compared to rest, P > 0.05. However, CBR-mediated decreases in percentage LVC in response to NP were attenuated in EL at both 7 W (16 ± 1{\%}) and 25 W (12 ± 1{\%}) compared to rest (40 ± 3{\%}; P < 0.05) as well as compared to responses in the NEL (36 ± 6{\%} at 7 W and 36 ± 7{\%} at 25 W; P < 0.05). This decrease in vascular responsiveness in EL was associated with a reduction in the gain of the percentage muscle sympathetic nerve activity ({\%}MSNA)-{\%}LVC relationship compared to rest (P < 0.05). Collectively, these data indicate that, despite a clear attenuation of the vascular response to MSNA in the exercising leg, CBR-mediated changes in mean arterial pressure were no different between rest and exercise.",
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Carotid baroreflex control of leg vasculature in exercising and non-exercising skeletal muscle in humans. / Keller, David Melvin; Fadel, Paul J.; Ogoh, Shigehiko; Brothers, Robert Matthews; Hawkins, Megan; Yurvati, Albert; Raven, Peter B.

In: Journal of Physiology, Vol. 561, No. 1, 15.11.2004, p. 283-293.

Research output: Contribution to journalArticleResearchpeer-review

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