Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment

Raul Vintimilla, Kishore Balasubramanian, James Hall, Leigh Johnson, Sid O'Bryant

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). Methods: Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report and/or standardized procedures. Cognitive function was measured with MMSE, Logical Memory I and II, Trail A & B, FAS, animal naming, and digit span tests. Independent samples t tests and two-way ANOVAs were conducted for analyses, adjusting for relevant covariates. We studied 100 Mexican Americans (65 female) with MCI, ages 50-86, from a longitudinal study of cognitive aging conducted at the University of North Texas Health Science Center. Results: A difference between subjects with and without obesity and memory scores was shown by t tests. Two-way ANOVAs detected an association between the coexistence of hypertension and diabetes with language measures, diabetes and dyslipidemia with executive function, and diabetes and obesity with memory and language measures. Conclusions: This study provides additional evidence about the link between cardiovascular risk factors and cognitive dysfunction in MCI subjects, and also demonstrated that comorbid risk factors increased the degree of cognitive deficit in many areas, which may indicate a higher risk of developing dementia.

Original languageEnglish
Pages (from-to)154-162
Number of pages9
JournalDementia and Geriatric Cognitive Disorders Extra
Volume10
Issue number3
DOIs
StatePublished - Sep 2020

Keywords

  • Cardiovascular risk factors
  • Mexican American
  • Mild cognitive impairment

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