TY - JOUR
T1 - Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment
AU - Vintimilla, Raul
AU - Balasubramanian, Kishore
AU - Hall, James
AU - Johnson, Leigh
AU - O'Bryant, Sid
N1 - Funding Information:
Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG054073. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. R.V. is also supported by award number RO1AG054073-02S1 Health Disparities in Alzheimer’s Disease and Mild Cognitive Impairment among Mexican Americans – Diversity Supplement.
Publisher Copyright:
© 2020 S. Karger AG. All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - Objectives: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). Methods: Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report and/or standardized procedures. Cognitive function was measured with MMSE, Logical Memory I and II, Trail A & B, FAS, animal naming, and digit span tests. Independent samples t tests and two-way ANOVAs were conducted for analyses, adjusting for relevant covariates. We studied 100 Mexican Americans (65 female) with MCI, ages 50-86, from a longitudinal study of cognitive aging conducted at the University of North Texas Health Science Center. Results: A difference between subjects with and without obesity and memory scores was shown by t tests. Two-way ANOVAs detected an association between the coexistence of hypertension and diabetes with language measures, diabetes and dyslipidemia with executive function, and diabetes and obesity with memory and language measures. Conclusions: This study provides additional evidence about the link between cardiovascular risk factors and cognitive dysfunction in MCI subjects, and also demonstrated that comorbid risk factors increased the degree of cognitive deficit in many areas, which may indicate a higher risk of developing dementia.
AB - Objectives: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). Methods: Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report and/or standardized procedures. Cognitive function was measured with MMSE, Logical Memory I and II, Trail A & B, FAS, animal naming, and digit span tests. Independent samples t tests and two-way ANOVAs were conducted for analyses, adjusting for relevant covariates. We studied 100 Mexican Americans (65 female) with MCI, ages 50-86, from a longitudinal study of cognitive aging conducted at the University of North Texas Health Science Center. Results: A difference between subjects with and without obesity and memory scores was shown by t tests. Two-way ANOVAs detected an association between the coexistence of hypertension and diabetes with language measures, diabetes and dyslipidemia with executive function, and diabetes and obesity with memory and language measures. Conclusions: This study provides additional evidence about the link between cardiovascular risk factors and cognitive dysfunction in MCI subjects, and also demonstrated that comorbid risk factors increased the degree of cognitive deficit in many areas, which may indicate a higher risk of developing dementia.
KW - Cardiovascular risk factors
KW - Mexican American
KW - Mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85096589361&partnerID=8YFLogxK
U2 - 10.1159/000511103
DO - 10.1159/000511103
M3 - Article
AN - SCOPUS:85096589361
SN - 1664-5464
VL - 10
SP - 154
EP - 162
JO - Dementia and Geriatric Cognitive Disorders Extra
JF - Dementia and Geriatric Cognitive Disorders Extra
IS - 3
ER -