Cardiovascular Neuroendocrinology: Emerging Role for Neurohypophyseal Hormones in Pathophysiology

Ato O. Aikins; Dianna H. Nguyen; Obed Paundralingga; George E. Farmer; Caroline Gusson Shimoura; Courtney Brock; J. Thomas Cunningham

doi:10.1210/endocr/bqab082

Cardiovascular Neuroendocrinology: Emerging Role for Neurohypophyseal Hormones in Pathophysiology

Ato O. Aikins, Dianna H. Nguyen, Obed Paundralingga, George E. Farmer, Caroline Gusson Shimoura, Courtney Brock, J. Thomas Cunningham

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Arginine vasopressin (AVP) and oxytocin (OXY) are released by magnocellular neurosecretory cells that project to the posterior pituitary. While AVP and OXY currently receive more attention for their contributions to affiliative behavior, this mini-review discusses their roles in cardiovascular function broadly defined to include indirect effects that influence cardiovascular function. The traditional view is that neither AVP nor OXY contributes to basal cardiovascular function, although some recent studies suggest that this position might be re-evaluated. More evidence indicates that adaptations and neuroplasticity of AVP and OXY neurons contribute to cardiovascular pathophysiology.

Original language	English
Article number	bqab082
Journal	Endocrinology (United States)
Volume	162
Issue number	8
DOIs	https://doi.org/10.1210/endocr/bqab082
State	Published - 1 Aug 2021

Keywords

heart failure
hypertension
oxytocin
vasopressin

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title = "Cardiovascular Neuroendocrinology: Emerging Role for Neurohypophyseal Hormones in Pathophysiology",

abstract = "Arginine vasopressin (AVP) and oxytocin (OXY) are released by magnocellular neurosecretory cells that project to the posterior pituitary. While AVP and OXY currently receive more attention for their contributions to affiliative behavior, this mini-review discusses their roles in cardiovascular function broadly defined to include indirect effects that influence cardiovascular function. The traditional view is that neither AVP nor OXY contributes to basal cardiovascular function, although some recent studies suggest that this position might be re-evaluated. More evidence indicates that adaptations and neuroplasticity of AVP and OXY neurons contribute to cardiovascular pathophysiology.",

keywords = "heart failure, hypertension, oxytocin, vasopressin",

author = "Aikins, {Ato O.} and Nguyen, {Dianna H.} and Obed Paundralingga and Farmer, {George E.} and Shimoura, {Caroline Gusson} and Courtney Brock and Cunningham, {J. Thomas}",

note = "Funding Information: This work was supported by the National Institutes of Health/ National Institute on Aging T32 grant AG020494 and National Institutes of Health/National Heart Lung and Blood Institute grants P01 088052, R01 HL142341, and R01 155977. Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.",

year = "2021",

month = aug,

day = "1",

doi = "10.1210/endocr/bqab082",

language = "English",

volume = "162",

journal = "Endocrinology",

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T2 - Emerging Role for Neurohypophyseal Hormones in Pathophysiology

AU - Aikins, Ato O.

AU - Nguyen, Dianna H.

AU - Paundralingga, Obed

AU - Farmer, George E.

AU - Shimoura, Caroline Gusson

AU - Brock, Courtney

AU - Cunningham, J. Thomas

N1 - Funding Information: This work was supported by the National Institutes of Health/ National Institute on Aging T32 grant AG020494 and National Institutes of Health/National Heart Lung and Blood Institute grants P01 088052, R01 HL142341, and R01 155977. Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.

PY - 2021/8/1

Y1 - 2021/8/1

N2 - Arginine vasopressin (AVP) and oxytocin (OXY) are released by magnocellular neurosecretory cells that project to the posterior pituitary. While AVP and OXY currently receive more attention for their contributions to affiliative behavior, this mini-review discusses their roles in cardiovascular function broadly defined to include indirect effects that influence cardiovascular function. The traditional view is that neither AVP nor OXY contributes to basal cardiovascular function, although some recent studies suggest that this position might be re-evaluated. More evidence indicates that adaptations and neuroplasticity of AVP and OXY neurons contribute to cardiovascular pathophysiology.

AB - Arginine vasopressin (AVP) and oxytocin (OXY) are released by magnocellular neurosecretory cells that project to the posterior pituitary. While AVP and OXY currently receive more attention for their contributions to affiliative behavior, this mini-review discusses their roles in cardiovascular function broadly defined to include indirect effects that influence cardiovascular function. The traditional view is that neither AVP nor OXY contributes to basal cardiovascular function, although some recent studies suggest that this position might be re-evaluated. More evidence indicates that adaptations and neuroplasticity of AVP and OXY neurons contribute to cardiovascular pathophysiology.

KW - heart failure

KW - hypertension

KW - oxytocin

KW - vasopressin

UR - http://www.scopus.com/inward/record.url?scp=85111784833&partnerID=8YFLogxK

U2 - 10.1210/endocr/bqab082

DO - 10.1210/endocr/bqab082

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C2 - 33891015

AN - SCOPUS:85111784833

SN - 0013-7227

VL - 162

JO - Endocrinology

JF - Endocrinology

IS - 8

M1 - bqab082

ER -

Cardiovascular Neuroendocrinology: Emerging Role for Neurohypophyseal Hormones in Pathophysiology

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Keywords

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