Cardiovascular Neuroendocrinology: Emerging Role for Neurohypophyseal Hormones in Pathophysiology

Ato O. Aikins, Dianna H. Nguyen, Obed Paundralingga, George E. Farmer, Caroline Gusson Shimoura, Courtney Brock, J. Thomas Cunningham

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Arginine vasopressin (AVP) and oxytocin (OXY) are released by magnocellular neurosecretory cells that project to the posterior pituitary. While AVP and OXY currently receive more attention for their contributions to affiliative behavior, this mini-review discusses their roles in cardiovascular function broadly defined to include indirect effects that influence cardiovascular function. The traditional view is that neither AVP nor OXY contributes to basal cardiovascular function, although some recent studies suggest that this position might be re-evaluated. More evidence indicates that adaptations and neuroplasticity of AVP and OXY neurons contribute to cardiovascular pathophysiology.

Original languageEnglish
Article numberbqab082
JournalEndocrinology (United States)
Issue number8
StatePublished - 1 Aug 2021


  • heart failure
  • hypertension
  • oxytocin
  • vasopressin


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