Cardiovascular effects of posterior hypothalamic stimulation in baroreflex-denervated rats

K. W. Barron, C. M. Heesch

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The overall purpose of this study was to examine the effect of sinoaortic baroreceptor denervation (SAD) on the cardiovascular and sympathetic outflow responses to electrical stimulation of the posterior hypothalamus. In anesthetized rats that had undergone SAD 7-10 days before experimentation, electrical stimulation of the posterior hypothalamus elicited greater increases in mean arterial pressure, iliac vascular resistance, mesenteric vascular resistance, and lumbar sympathetic nerve activity than in sham-operated baroreceptor-intact animals. Similarly, the pressor effects of intravenous norepinephrine were also augmented in the baroreceptor-denervated group compared with the baroreceptor-intact group. When posterior hypothalamic and intravenous norepinephrine pressor stimuli, which produced equivalent pressor responses in sham-operated baroreceptor-intact animals, were compared in baroreceptor-denervated animals, the pressor effects of the central hypothalamic stimulus were enhanced to a greater degree than the norepinephrine pressor effects. These data provide evidence that arterial baroreceptor reflexes exert greater buffering of pressor stimuli initiated from the central nervous system compared with pressor responses due to peripheral vascular vasoconstrictor agents.

Original languageEnglish
Pages (from-to)H720-H727
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume259
Issue number3 28-3
DOIs
StatePublished - 1990

Keywords

  • arterial baroreceptor reflex
  • arterial blood pressure
  • heart rate
  • iliac blood flow
  • lumbar sympathetic nerve activity
  • mesenteric blood flow
  • sinoaortic baroreceptor denervation

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