Cardiovascular effects of neuropeptide FF antagonists

Laszlo Prokai, Alevtina D. Zharikova, Attila Juhasz, Katalin Prokai-Tatrai

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The neuropeptide FF (NPFF) antagonist desaminotyrosyl-Phe-Leu-Phe-Gln-Pro-Gln-Arg-NH2 dose-dependently reversed NPFF-induced elevation of blood pressure in anesthetized rats after intravenous injection without causing a significant change of blood pressure and heart rate by itself. However, another antagonist dansyl-Pro-Gln-Arg-NH2 produced a significant drop of the mean arterial pressure only at a large dose (10 μmol/kg body weight), but reversal of the NPFF-induced hypertension was modest. Consequently and contrary to the conclusions of a previous study, NPFF antagonists cannot be identified simply by measuring the changes in the hemodynamic parameters upon the injection of the compounds alone and without a subsequent NPFF challenge.

Original languageEnglish
Pages (from-to)1015-1019
Number of pages5
JournalPeptides
Volume27
Issue number5
DOIs
StatePublished - 1 May 2006

Keywords

  • Antagonist
  • Hemodynamic parameters
  • Neuropeptide FF
  • Rat

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