Cardiovascular effects of neuropeptide FF antagonists

Laszlo Prokai; Alevtina D. Zharikova; Attila Juhasz; Katalin Prokai-Tatrai

doi:10.1016/j.peptides.2005.06.032

Cardiovascular effects of neuropeptide FF antagonists

Laszlo Prokai, Alevtina D. Zharikova, Attila Juhasz, Katalin Prokai-Tatrai

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The neuropeptide FF (NPFF) antagonist desaminotyrosyl-Phe-Leu-Phe-Gln-Pro-Gln-Arg-NH₂ dose-dependently reversed NPFF-induced elevation of blood pressure in anesthetized rats after intravenous injection without causing a significant change of blood pressure and heart rate by itself. However, another antagonist dansyl-Pro-Gln-Arg-NH₂ produced a significant drop of the mean arterial pressure only at a large dose (10 μmol/kg body weight), but reversal of the NPFF-induced hypertension was modest. Consequently and contrary to the conclusions of a previous study, NPFF antagonists cannot be identified simply by measuring the changes in the hemodynamic parameters upon the injection of the compounds alone and without a subsequent NPFF challenge.

Original language	English
Pages (from-to)	1015-1019
Number of pages	5
Journal	Peptides
Volume	27
Issue number	5
DOIs	https://doi.org/10.1016/j.peptides.2005.06.032
State	Published - May 2006

Keywords

Antagonist
Hemodynamic parameters
Neuropeptide FF
Rat

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10.1016/j.peptides.2005.06.032

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title = "Cardiovascular effects of neuropeptide FF antagonists",

abstract = "The neuropeptide FF (NPFF) antagonist desaminotyrosyl-Phe-Leu-Phe-Gln-Pro-Gln-Arg-NH2 dose-dependently reversed NPFF-induced elevation of blood pressure in anesthetized rats after intravenous injection without causing a significant change of blood pressure and heart rate by itself. However, another antagonist dansyl-Pro-Gln-Arg-NH2 produced a significant drop of the mean arterial pressure only at a large dose (10 μmol/kg body weight), but reversal of the NPFF-induced hypertension was modest. Consequently and contrary to the conclusions of a previous study, NPFF antagonists cannot be identified simply by measuring the changes in the hemodynamic parameters upon the injection of the compounds alone and without a subsequent NPFF challenge.",

keywords = "Antagonist, Hemodynamic parameters, Neuropeptide FF, Rat",

author = "Laszlo Prokai and Zharikova, {Alevtina D.} and Attila Juhasz and Katalin Prokai-Tatrai",

note = "Funding Information: This work was supported by the National Institute on Drug Abuse (Grant number DA10543). Instruments for recording cardiovascular parameters were provided by the Center for Drug Discovery, Department of Pharmaceutics, College of Pharmacy at the University of Florida. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.peptides.2005.06.032",

language = "English",

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journal = "Peptides",

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T1 - Cardiovascular effects of neuropeptide FF antagonists

AU - Prokai, Laszlo

AU - Zharikova, Alevtina D.

AU - Juhasz, Attila

AU - Prokai-Tatrai, Katalin

N1 - Funding Information: This work was supported by the National Institute on Drug Abuse (Grant number DA10543). Instruments for recording cardiovascular parameters were provided by the Center for Drug Discovery, Department of Pharmaceutics, College of Pharmacy at the University of Florida. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2006/5

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N2 - The neuropeptide FF (NPFF) antagonist desaminotyrosyl-Phe-Leu-Phe-Gln-Pro-Gln-Arg-NH2 dose-dependently reversed NPFF-induced elevation of blood pressure in anesthetized rats after intravenous injection without causing a significant change of blood pressure and heart rate by itself. However, another antagonist dansyl-Pro-Gln-Arg-NH2 produced a significant drop of the mean arterial pressure only at a large dose (10 μmol/kg body weight), but reversal of the NPFF-induced hypertension was modest. Consequently and contrary to the conclusions of a previous study, NPFF antagonists cannot be identified simply by measuring the changes in the hemodynamic parameters upon the injection of the compounds alone and without a subsequent NPFF challenge.

AB - The neuropeptide FF (NPFF) antagonist desaminotyrosyl-Phe-Leu-Phe-Gln-Pro-Gln-Arg-NH2 dose-dependently reversed NPFF-induced elevation of blood pressure in anesthetized rats after intravenous injection without causing a significant change of blood pressure and heart rate by itself. However, another antagonist dansyl-Pro-Gln-Arg-NH2 produced a significant drop of the mean arterial pressure only at a large dose (10 μmol/kg body weight), but reversal of the NPFF-induced hypertension was modest. Consequently and contrary to the conclusions of a previous study, NPFF antagonists cannot be identified simply by measuring the changes in the hemodynamic parameters upon the injection of the compounds alone and without a subsequent NPFF challenge.

KW - Antagonist

KW - Hemodynamic parameters

KW - Neuropeptide FF

KW - Rat

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DO - 10.1016/j.peptides.2005.06.032

M3 - Article

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AN - SCOPUS:33646147383

SN - 0196-9781

VL - 27

SP - 1015

EP - 1019

JO - Peptides

JF - Peptides

IS - 5

ER -

Cardiovascular effects of neuropeptide FF antagonists

Abstract

Keywords

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