Cardiovascular deficits after lesions of C1 adrenergic neurons with a saporin-based immunotoxin

Patrice G. Guyenet, Ruth L. Stornetta, Ann M. Schreihofer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Central nervous system (CNS) adrenergic neurons are located exclusively in the medulla oblongata (1). The metabolism of CNS adrenaline, its turnover rate, and its pharmacology were intensely studied in the late 1970s (reviewed in ref. 2). Since then, the study of CNS adrenergic neurons has been the purview of integrative physiologists interested in stress, autonomic regulations, and the neural control of blood pressure and glucose. The CNS contains three clusters of adrenergic neurons: C1, C2, and C3 (1). The main focus of this chapter is on the C1 neurons, especially those with spinal projections that are most important for sympathetic control and blood pressure regulation (3-6).

Original languageEnglish
Title of host publicationMolecular Neurosurgery With Targeted Toxins
PublisherHumana Press
Pages219-233
Number of pages15
ISBN (Print)9781588291998
DOIs
StatePublished - 1 Dec 2005

Fingerprint Dive into the research topics of 'Cardiovascular deficits after lesions of C1 adrenergic neurons with a saporin-based immunotoxin'. Together they form a unique fingerprint.

  • Cite this

    Guyenet, P. G., Stornetta, R. L., & Schreihofer, A. M. (2005). Cardiovascular deficits after lesions of C1 adrenergic neurons with a saporin-based immunotoxin. In Molecular Neurosurgery With Targeted Toxins (pp. 219-233). Humana Press. https://doi.org/10.1007/978-1-59259-896-0_9