Cardiopulmonary baroreflex is reset during dynamic exercise

Shigehiko Ogoh, R. Matthew Brothers, Quinton Barnes, Wendy L. Eubank, Megan N. Hawkins, Sushmita Purkayastha, Albert Yurvati, Peter B. Raven

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

The purpose of this study was to examine the hypothesis that the operating point of the cardiopulmonary baroreflex resets to the higher cardiac filling pressure of exercise associated with the increased cardiac filling volumes. Eight men (age 26 ± 1 yr; height 180 ± 3 cm; weight 86 ± 6 kg; means ± SE) participated in the present study. Lower body negative pressure (LBNP) was applied at 8 and 16 Torr to decrease central venous pressure (CVP) at rest and during steady-state leg cycling at 50% peak oxygen uptake (104 ± 20 W). Subsequently, two discrete infusions of 25% human serum albumin solution were administered until CVP was increased by 1.8 plusmn; 0.6 and 2.4 ± 0.4 mmHg at rest and 2.9 ± 0.9 and 4.6 ± 0.9 mmHg during exercise. During all protocols, heart rate, arterial blood pressure, and CVP were recorded continuously. At each stage of LBNP or albumin infusion, forearm blood flow and cardiac output were measured. During exercise, forearm vascular conductance increased from 7.5 ± 0.5 to 8.7 ± 0.6 U (P ± 0.024) and total systemic vascular conductance from 7.2 ± 0.2 to 13.5 ± 0.9 l·min -1·mmHg -1 (P < 0.001). However, there was no significant difference in the responses of both forearm vascular conductance and total systemic vascular conductance to LBNP and the infusion of albumin between rest and exercise. These data indicate that the cardiopulmonary baroreflex had been reset during exercise to the new operating point associated with the exercise-induced change in cardiac filling volume.

Original languageEnglish
Pages (from-to)51-59
Number of pages9
JournalJournal of Applied Physiology
Volume100
Issue number1
DOIs
StatePublished - 1 Jan 2006

Fingerprint

Baroreflex
Lower Body Negative Pressure
Exercise
Central Venous Pressure
Blood Vessels
Forearm
Cardiac Volume
Albumins
Serum Albumin
Cardiac Output
Leg
Arterial Pressure
Heart Rate
Oxygen
Pressure
Weights and Measures

Keywords

  • Blood pressure
  • Central blood volume
  • Forearm blood flow

Cite this

Ogoh, S., Brothers, R. M., Barnes, Q., Eubank, W. L., Hawkins, M. N., Purkayastha, S., ... Raven, P. B. (2006). Cardiopulmonary baroreflex is reset during dynamic exercise. Journal of Applied Physiology, 100(1), 51-59. https://doi.org/10.1152/japplphysiol.00804.2005
Ogoh, Shigehiko ; Brothers, R. Matthew ; Barnes, Quinton ; Eubank, Wendy L. ; Hawkins, Megan N. ; Purkayastha, Sushmita ; Yurvati, Albert ; Raven, Peter B. / Cardiopulmonary baroreflex is reset during dynamic exercise. In: Journal of Applied Physiology. 2006 ; Vol. 100, No. 1. pp. 51-59.
@article{0efe26966364471387963e9be96f2b9a,
title = "Cardiopulmonary baroreflex is reset during dynamic exercise",
abstract = "The purpose of this study was to examine the hypothesis that the operating point of the cardiopulmonary baroreflex resets to the higher cardiac filling pressure of exercise associated with the increased cardiac filling volumes. Eight men (age 26 ± 1 yr; height 180 ± 3 cm; weight 86 ± 6 kg; means ± SE) participated in the present study. Lower body negative pressure (LBNP) was applied at 8 and 16 Torr to decrease central venous pressure (CVP) at rest and during steady-state leg cycling at 50{\%} peak oxygen uptake (104 ± 20 W). Subsequently, two discrete infusions of 25{\%} human serum albumin solution were administered until CVP was increased by 1.8 plusmn; 0.6 and 2.4 ± 0.4 mmHg at rest and 2.9 ± 0.9 and 4.6 ± 0.9 mmHg during exercise. During all protocols, heart rate, arterial blood pressure, and CVP were recorded continuously. At each stage of LBNP or albumin infusion, forearm blood flow and cardiac output were measured. During exercise, forearm vascular conductance increased from 7.5 ± 0.5 to 8.7 ± 0.6 U (P ± 0.024) and total systemic vascular conductance from 7.2 ± 0.2 to 13.5 ± 0.9 l·min -1·mmHg -1 (P < 0.001). However, there was no significant difference in the responses of both forearm vascular conductance and total systemic vascular conductance to LBNP and the infusion of albumin between rest and exercise. These data indicate that the cardiopulmonary baroreflex had been reset during exercise to the new operating point associated with the exercise-induced change in cardiac filling volume.",
keywords = "Blood pressure, Central blood volume, Forearm blood flow",
author = "Shigehiko Ogoh and Brothers, {R. Matthew} and Quinton Barnes and Eubank, {Wendy L.} and Hawkins, {Megan N.} and Sushmita Purkayastha and Albert Yurvati and Raven, {Peter B.}",
year = "2006",
month = "1",
day = "1",
doi = "10.1152/japplphysiol.00804.2005",
language = "English",
volume = "100",
pages = "51--59",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "1",

}

Ogoh, S, Brothers, RM, Barnes, Q, Eubank, WL, Hawkins, MN, Purkayastha, S, Yurvati, A & Raven, PB 2006, 'Cardiopulmonary baroreflex is reset during dynamic exercise', Journal of Applied Physiology, vol. 100, no. 1, pp. 51-59. https://doi.org/10.1152/japplphysiol.00804.2005

Cardiopulmonary baroreflex is reset during dynamic exercise. / Ogoh, Shigehiko; Brothers, R. Matthew; Barnes, Quinton; Eubank, Wendy L.; Hawkins, Megan N.; Purkayastha, Sushmita; Yurvati, Albert; Raven, Peter B.

In: Journal of Applied Physiology, Vol. 100, No. 1, 01.01.2006, p. 51-59.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Cardiopulmonary baroreflex is reset during dynamic exercise

AU - Ogoh, Shigehiko

AU - Brothers, R. Matthew

AU - Barnes, Quinton

AU - Eubank, Wendy L.

AU - Hawkins, Megan N.

AU - Purkayastha, Sushmita

AU - Yurvati, Albert

AU - Raven, Peter B.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - The purpose of this study was to examine the hypothesis that the operating point of the cardiopulmonary baroreflex resets to the higher cardiac filling pressure of exercise associated with the increased cardiac filling volumes. Eight men (age 26 ± 1 yr; height 180 ± 3 cm; weight 86 ± 6 kg; means ± SE) participated in the present study. Lower body negative pressure (LBNP) was applied at 8 and 16 Torr to decrease central venous pressure (CVP) at rest and during steady-state leg cycling at 50% peak oxygen uptake (104 ± 20 W). Subsequently, two discrete infusions of 25% human serum albumin solution were administered until CVP was increased by 1.8 plusmn; 0.6 and 2.4 ± 0.4 mmHg at rest and 2.9 ± 0.9 and 4.6 ± 0.9 mmHg during exercise. During all protocols, heart rate, arterial blood pressure, and CVP were recorded continuously. At each stage of LBNP or albumin infusion, forearm blood flow and cardiac output were measured. During exercise, forearm vascular conductance increased from 7.5 ± 0.5 to 8.7 ± 0.6 U (P ± 0.024) and total systemic vascular conductance from 7.2 ± 0.2 to 13.5 ± 0.9 l·min -1·mmHg -1 (P < 0.001). However, there was no significant difference in the responses of both forearm vascular conductance and total systemic vascular conductance to LBNP and the infusion of albumin between rest and exercise. These data indicate that the cardiopulmonary baroreflex had been reset during exercise to the new operating point associated with the exercise-induced change in cardiac filling volume.

AB - The purpose of this study was to examine the hypothesis that the operating point of the cardiopulmonary baroreflex resets to the higher cardiac filling pressure of exercise associated with the increased cardiac filling volumes. Eight men (age 26 ± 1 yr; height 180 ± 3 cm; weight 86 ± 6 kg; means ± SE) participated in the present study. Lower body negative pressure (LBNP) was applied at 8 and 16 Torr to decrease central venous pressure (CVP) at rest and during steady-state leg cycling at 50% peak oxygen uptake (104 ± 20 W). Subsequently, two discrete infusions of 25% human serum albumin solution were administered until CVP was increased by 1.8 plusmn; 0.6 and 2.4 ± 0.4 mmHg at rest and 2.9 ± 0.9 and 4.6 ± 0.9 mmHg during exercise. During all protocols, heart rate, arterial blood pressure, and CVP were recorded continuously. At each stage of LBNP or albumin infusion, forearm blood flow and cardiac output were measured. During exercise, forearm vascular conductance increased from 7.5 ± 0.5 to 8.7 ± 0.6 U (P ± 0.024) and total systemic vascular conductance from 7.2 ± 0.2 to 13.5 ± 0.9 l·min -1·mmHg -1 (P < 0.001). However, there was no significant difference in the responses of both forearm vascular conductance and total systemic vascular conductance to LBNP and the infusion of albumin between rest and exercise. These data indicate that the cardiopulmonary baroreflex had been reset during exercise to the new operating point associated with the exercise-induced change in cardiac filling volume.

KW - Blood pressure

KW - Central blood volume

KW - Forearm blood flow

UR - http://www.scopus.com/inward/record.url?scp=33644817770&partnerID=8YFLogxK

U2 - 10.1152/japplphysiol.00804.2005

DO - 10.1152/japplphysiol.00804.2005

M3 - Article

VL - 100

SP - 51

EP - 59

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 1

ER -

Ogoh S, Brothers RM, Barnes Q, Eubank WL, Hawkins MN, Purkayastha S et al. Cardiopulmonary baroreflex is reset during dynamic exercise. Journal of Applied Physiology. 2006 Jan 1;100(1):51-59. https://doi.org/10.1152/japplphysiol.00804.2005