Cardiac structure and function in well-healed burn survivors

T. Jake Samuel, Michael D. Nelson, Aida Nasirian, Manall Jaffery, Gilbert Moralez, Steven Anthony Romero, Matthew N. Cramer, Mu Huang, Ken Kouda, Michinari Hieda, Satyam Sarma, Craig G. Crandall

Research output: Contribution to journalArticle

Abstract

Long-Term burn survivors have reduced aerobic capacity, placing them at increased risk for cardiovascular disease, morbidity, and mortality. However, the exact mechanism contributing to a reduced aerobic capacity remains incompletely understood, but may be related to adverse cardiovascular remodeling. Therefore, it was hypothesized that well-healed burn survivors would exhibit adverse left ventricular (LV) remodeling and impaired LV function. To test this hypothesis, 22 well-healed moderately burned individuals (age: 41 ± 14 years; BMI: 27.7 ± 5.4 kg/m 2; male/female: 12/10; extent of burn: 37 ± 12 %BSA), 11 well-healed severely burned individuals (age: 43 ± 12 years; BMI: 29.5 ± 5.8 kg/m 2; male/female: 8/3; extent of burn: 73 ± 11 %BSA), and 12 healthy, age-matched controls (age: 34 ± 9 years; BMI: 28.6 ± 5.2 kg/m 2; male/female: 5/7) were enrolled in the study. All subjects were sedentary, performing less than 30 minutes of aerobic exercise per day, 3 days per week. LV morphology and function were assessed via cardiac magnetic resonance imaging. In contrast to the hypothesis, neither the presence nor severity of burn injury adversely affected LV morphology or function, when compared with equally sedentary nonburned controls. However, of note, LV mass of all three groups was in the lowest 5th percentile compared with normative values. Finally, group differences in LV morphology were largely explained by differences in aerobic capacity. Taken together, these data suggest a prior burn injury itself does not result in pathological remodeling of the LV and support a role for aerobic exercise training to improve cardiac function.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalJournal of Burn Care and Research
Volume40
Issue number2
DOIs
StatePublished - 20 Feb 2019

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Survivors
Ventricular Remodeling
Exercise
Left Ventricular Function
Wounds and Injuries
Cardiovascular Diseases
Magnetic Resonance Imaging
Morbidity
Mortality

Cite this

Samuel, T. J., Nelson, M. D., Nasirian, A., Jaffery, M., Moralez, G., Romero, S. A., ... Crandall, C. G. (2019). Cardiac structure and function in well-healed burn survivors. Journal of Burn Care and Research, 40(2), 235-241. https://doi.org/10.1093/jbcr/irz008
Samuel, T. Jake ; Nelson, Michael D. ; Nasirian, Aida ; Jaffery, Manall ; Moralez, Gilbert ; Romero, Steven Anthony ; Cramer, Matthew N. ; Huang, Mu ; Kouda, Ken ; Hieda, Michinari ; Sarma, Satyam ; Crandall, Craig G. / Cardiac structure and function in well-healed burn survivors. In: Journal of Burn Care and Research. 2019 ; Vol. 40, No. 2. pp. 235-241.
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abstract = "Long-Term burn survivors have reduced aerobic capacity, placing them at increased risk for cardiovascular disease, morbidity, and mortality. However, the exact mechanism contributing to a reduced aerobic capacity remains incompletely understood, but may be related to adverse cardiovascular remodeling. Therefore, it was hypothesized that well-healed burn survivors would exhibit adverse left ventricular (LV) remodeling and impaired LV function. To test this hypothesis, 22 well-healed moderately burned individuals (age: 41 ± 14 years; BMI: 27.7 ± 5.4 kg/m 2; male/female: 12/10; extent of burn: 37 ± 12 {\%}BSA), 11 well-healed severely burned individuals (age: 43 ± 12 years; BMI: 29.5 ± 5.8 kg/m 2; male/female: 8/3; extent of burn: 73 ± 11 {\%}BSA), and 12 healthy, age-matched controls (age: 34 ± 9 years; BMI: 28.6 ± 5.2 kg/m 2; male/female: 5/7) were enrolled in the study. All subjects were sedentary, performing less than 30 minutes of aerobic exercise per day, 3 days per week. LV morphology and function were assessed via cardiac magnetic resonance imaging. In contrast to the hypothesis, neither the presence nor severity of burn injury adversely affected LV morphology or function, when compared with equally sedentary nonburned controls. However, of note, LV mass of all three groups was in the lowest 5th percentile compared with normative values. Finally, group differences in LV morphology were largely explained by differences in aerobic capacity. Taken together, these data suggest a prior burn injury itself does not result in pathological remodeling of the LV and support a role for aerobic exercise training to improve cardiac function.",
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Samuel, TJ, Nelson, MD, Nasirian, A, Jaffery, M, Moralez, G, Romero, SA, Cramer, MN, Huang, M, Kouda, K, Hieda, M, Sarma, S & Crandall, CG 2019, 'Cardiac structure and function in well-healed burn survivors', Journal of Burn Care and Research, vol. 40, no. 2, pp. 235-241. https://doi.org/10.1093/jbcr/irz008

Cardiac structure and function in well-healed burn survivors. / Samuel, T. Jake; Nelson, Michael D.; Nasirian, Aida; Jaffery, Manall; Moralez, Gilbert; Romero, Steven Anthony; Cramer, Matthew N.; Huang, Mu; Kouda, Ken; Hieda, Michinari; Sarma, Satyam; Crandall, Craig G.

In: Journal of Burn Care and Research, Vol. 40, No. 2, 20.02.2019, p. 235-241.

Research output: Contribution to journalArticle

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T1 - Cardiac structure and function in well-healed burn survivors

AU - Samuel, T. Jake

AU - Nelson, Michael D.

AU - Nasirian, Aida

AU - Jaffery, Manall

AU - Moralez, Gilbert

AU - Romero, Steven Anthony

AU - Cramer, Matthew N.

AU - Huang, Mu

AU - Kouda, Ken

AU - Hieda, Michinari

AU - Sarma, Satyam

AU - Crandall, Craig G.

PY - 2019/2/20

Y1 - 2019/2/20

N2 - Long-Term burn survivors have reduced aerobic capacity, placing them at increased risk for cardiovascular disease, morbidity, and mortality. However, the exact mechanism contributing to a reduced aerobic capacity remains incompletely understood, but may be related to adverse cardiovascular remodeling. Therefore, it was hypothesized that well-healed burn survivors would exhibit adverse left ventricular (LV) remodeling and impaired LV function. To test this hypothesis, 22 well-healed moderately burned individuals (age: 41 ± 14 years; BMI: 27.7 ± 5.4 kg/m 2; male/female: 12/10; extent of burn: 37 ± 12 %BSA), 11 well-healed severely burned individuals (age: 43 ± 12 years; BMI: 29.5 ± 5.8 kg/m 2; male/female: 8/3; extent of burn: 73 ± 11 %BSA), and 12 healthy, age-matched controls (age: 34 ± 9 years; BMI: 28.6 ± 5.2 kg/m 2; male/female: 5/7) were enrolled in the study. All subjects were sedentary, performing less than 30 minutes of aerobic exercise per day, 3 days per week. LV morphology and function were assessed via cardiac magnetic resonance imaging. In contrast to the hypothesis, neither the presence nor severity of burn injury adversely affected LV morphology or function, when compared with equally sedentary nonburned controls. However, of note, LV mass of all three groups was in the lowest 5th percentile compared with normative values. Finally, group differences in LV morphology were largely explained by differences in aerobic capacity. Taken together, these data suggest a prior burn injury itself does not result in pathological remodeling of the LV and support a role for aerobic exercise training to improve cardiac function.

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Samuel TJ, Nelson MD, Nasirian A, Jaffery M, Moralez G, Romero SA et al. Cardiac structure and function in well-healed burn survivors. Journal of Burn Care and Research. 2019 Feb 20;40(2):235-241. https://doi.org/10.1093/jbcr/irz008