Canonical transient receptor potential channels in diabetes

Sarabeth Graham, Joseph P. Yuan, Rong Ma

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Canonical transient receptor potential (TRPC) channel proteins have been identified as downstream molecules in a G proteincoupled receptor signaling pathway and are involved in a variety of cell functions due to their ability to regulate intracellular calcium signaling. TRPC channel physiology has been an increasingly interesting and relevant topic over the last decade, and the outcomes from various studies have advanced our understanding of TRPC function in the normal state. Recently, attention has turned to whether or not TRPC proteins are implicated in diseases. Emerging evidence suggests a significant contribution of several isoforms of TRPC proteins to cardiovascular as well as renal diseases. This review focuses on the implication of TRPC proteins as they pertain to diabetes. We summarize the recent findings by other investigators as well as ourselves and additionally discuss the important role of TRPC proteins in the development of various diabetic complications, such as diabetic nephropathy and diabetic vasculopathy. The underlying mechanisms which contribute to these complications are also outlined. Lastly, we elaborate on the role of TRPC proteins as a potential therapeutic target for treating diabetesassociated diseases.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalExperimental Biology and Medicine
Volume237
Issue number2
DOIs
StatePublished - Feb 2012

Keywords

  • Calcium
  • Diabetes
  • Diabetic complications
  • TRPC

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