Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation

M. S. Kapiloff, J. M. Mathis, C. A. Nelson, C. R. Lin, M. G. Rosenfeld

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Abstract

Calcium influx in response to extracellular signals can modulate gene transcription. A constitutive, calcium/calmodulin-independent mutant of type II calcium/calmodulin-dependent protein kinase was capable of increasing the transcription rate of specific genes independently of protein kinase C activation. This increase was mediated by transferable cis-active elements capable of binding the transcription factor CAAT/enhancer binding protein. Therefore, the activation of type II calcium/calmodulin-dependent protein kinase in response to stimuli that increase intracellular calcium is proposed to represent a distinct second messenger pathway in calcium-mediated regulation of gene transcription.

Original languageEnglish
Pages (from-to)3710-3714
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume88
Issue number9
DOIs
StatePublished - 1 Jan 1991

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Keywords

  • CAAT
  • Rous sarcoma virus
  • enhancer binding protein
  • long terminal repeat
  • prolactin gene

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