Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation

M. S. Kapiloff; J. M. Mathis; C. A. Nelson; C. R. Lin; M. G. Rosenfeld

doi:10.1073/pnas.88.9.3710

Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation

M. S. Kapiloff, J. M. Mathis, C. A. Nelson, C. R. Lin, M. G. Rosenfeld

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Calcium influx in response to extracellular signals can modulate gene transcription. A constitutive, calcium/calmodulin-independent mutant of type II calcium/calmodulin-dependent protein kinase was capable of increasing the transcription rate of specific genes independently of protein kinase C activation. This increase was mediated by transferable cis-active elements capable of binding the transcription factor CAAT/enhancer binding protein. Therefore, the activation of type II calcium/calmodulin-dependent protein kinase in response to stimuli that increase intracellular calcium is proposed to represent a distinct second messenger pathway in calcium-mediated regulation of gene transcription.

Original language	English
Pages (from-to)	3710-3714
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	88
Issue number	9
DOIs	https://doi.org/10.1073/pnas.88.9.3710
State	Published - 1991

Keywords

CAAT
Rous sarcoma virus
enhancer binding protein
long terminal repeat
prolactin gene

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abstract = "Calcium influx in response to extracellular signals can modulate gene transcription. A constitutive, calcium/calmodulin-independent mutant of type II calcium/calmodulin-dependent protein kinase was capable of increasing the transcription rate of specific genes independently of protein kinase C activation. This increase was mediated by transferable cis-active elements capable of binding the transcription factor CAAT/enhancer binding protein. Therefore, the activation of type II calcium/calmodulin-dependent protein kinase in response to stimuli that increase intracellular calcium is proposed to represent a distinct second messenger pathway in calcium-mediated regulation of gene transcription.",

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AU - Mathis, J. M.

AU - Nelson, C. A.

AU - Lin, C. R.

AU - Rosenfeld, M. G.

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AB - Calcium influx in response to extracellular signals can modulate gene transcription. A constitutive, calcium/calmodulin-independent mutant of type II calcium/calmodulin-dependent protein kinase was capable of increasing the transcription rate of specific genes independently of protein kinase C activation. This increase was mediated by transferable cis-active elements capable of binding the transcription factor CAAT/enhancer binding protein. Therefore, the activation of type II calcium/calmodulin-dependent protein kinase in response to stimuli that increase intracellular calcium is proposed to represent a distinct second messenger pathway in calcium-mediated regulation of gene transcription.

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KW - Rous sarcoma virus

KW - enhancer binding protein

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KW - prolactin gene

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Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation

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