BW373U86, a δ-opioid receptor agonist, reverses bradykinin-induced thermal allodynia in rhesus monkeys

Eduardo R. Butelman, S. Stevens Negus, Michael B. Gatch, Kwen Jen Chang, James H. Woods

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The synthetic δ-opioid receptor agonist BW373U86 (0.18-0.56 mg/kg s.c.) was studied in rhesus monkeys with a warm-water, tail-withdrawal assay, designed to detect bradykinin (0.1 μg) and prostaglandin E2 (5-15.8 μg)-induced thermal allodynia. BW373U86 dose-dependently reversed bradykinin allodynia, but was ineffective against prostaglandin E2 allodynia. The BW373U86 dose-effect curve was shifted to the right by the δ-opioid receptor-selective antagonist naltrindole (1.0 mg/kg) but not by the μ-opioid receptor-selective antagonist quadazocine (0.1 mg/kg). The present findings add to the conditions in which δ-opioid receptor-mediated behavioral effects have been detected in primates, and suggest that δ-opioid agonists may be of therapeutic interest in the treatment of some types of hyperalgesic conditions.

Original languageEnglish
Pages (from-to)285-287
Number of pages3
JournalEuropean Journal of Pharmacology
Volume277
Issue number2-3
DOIs
StatePublished - 24 Apr 1995

Keywords

  • Allodynia
  • BW373U86
  • Hyperalgesia
  • Rhesus monkey
  • δ-Opioid receptor agonist

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