Abstract
This chapter reviews applications of magnetic nanoparticles in brain-targeting and diagnostic applications. Previously, nanoparticles have delivered drugs in blood circulation in a controlled manner and relied upon their predisposition to penetrate the bloodâ€"brain barrier. However, in order to increase the delivery efficiency and pharmacological effect, we need to design a better strategy. Herein, we show that externally applied magnetic fields can be used to target certain superparamagnetic particles to various organs. Various physical methods (UVâ€"Vis, TEM, dynamic light scattering, fluorescence, thermogravimetric analysis, FTIR, etc.) have been utilized to thoroughly characterize this hybrid nanoparticle formulation. Furthermore, the magnetic properties showcased by these particles are harnessed for the diagnosis of cancer and other disease treatment. Magnetic resonance imaging, with new modalities, is of immense help to physicians and researchers in identifying the tumor sites and demarcating the form of normal cells and blood vasculature. Recently, the therapeutic load carried by the efficiency of magnetic nanoparticles and the diagnostic nature of the same have been married to coin the term “theranosticsâ€?; it is gaining an increased momentum in the cancer field.
| Original language | English |
|---|---|
| Title of host publication | Nanostructures for the Engineering of Cells, Tissues and Organs |
| Subtitle of host publication | From Design to Applications |
| Publisher | Elsevier |
| Pages | 167-185 |
| Number of pages | 19 |
| ISBN (Electronic) | 9780128136669 |
| ISBN (Print) | 9780128136652 |
| DOIs | |
| State | Published - 16 Feb 2018 |
Fingerprint
Keywords
- Brain
- Diagnostic applications
- Magnetic
- Nanoparticle
- Site specific
- Targeting
Cite this
}
Brain targeting of payload using mild magnetic field : Site specific delivery. / Bommana, Murali M.; Raut, Sangram Limbaji.
Nanostructures for the Engineering of Cells, Tissues and Organs: From Design to Applications. Elsevier, 2018. p. 167-185.Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review
TY - CHAP
T1 - Brain targeting of payload using mild magnetic field
T2 - Site specific delivery
AU - Bommana, Murali M.
AU - Raut, Sangram Limbaji
PY - 2018/2/16
Y1 - 2018/2/16
N2 - This chapter reviews applications of magnetic nanoparticles in brain-targeting and diagnostic applications. Previously, nanoparticles have delivered drugs in blood circulation in a controlled manner and relied upon their predisposition to penetrate the bloodâ€"brain barrier. However, in order to increase the delivery efficiency and pharmacological effect, we need to design a better strategy. Herein, we show that externally applied magnetic fields can be used to target certain superparamagnetic particles to various organs. Various physical methods (UVâ€"Vis, TEM, dynamic light scattering, fluorescence, thermogravimetric analysis, FTIR, etc.) have been utilized to thoroughly characterize this hybrid nanoparticle formulation. Furthermore, the magnetic properties showcased by these particles are harnessed for the diagnosis of cancer and other disease treatment. Magnetic resonance imaging, with new modalities, is of immense help to physicians and researchers in identifying the tumor sites and demarcating the form of normal cells and blood vasculature. Recently, the therapeutic load carried by the efficiency of magnetic nanoparticles and the diagnostic nature of the same have been married to coin the term “theranosticsâ€?; it is gaining an increased momentum in the cancer field.
AB - This chapter reviews applications of magnetic nanoparticles in brain-targeting and diagnostic applications. Previously, nanoparticles have delivered drugs in blood circulation in a controlled manner and relied upon their predisposition to penetrate the bloodâ€"brain barrier. However, in order to increase the delivery efficiency and pharmacological effect, we need to design a better strategy. Herein, we show that externally applied magnetic fields can be used to target certain superparamagnetic particles to various organs. Various physical methods (UVâ€"Vis, TEM, dynamic light scattering, fluorescence, thermogravimetric analysis, FTIR, etc.) have been utilized to thoroughly characterize this hybrid nanoparticle formulation. Furthermore, the magnetic properties showcased by these particles are harnessed for the diagnosis of cancer and other disease treatment. Magnetic resonance imaging, with new modalities, is of immense help to physicians and researchers in identifying the tumor sites and demarcating the form of normal cells and blood vasculature. Recently, the therapeutic load carried by the efficiency of magnetic nanoparticles and the diagnostic nature of the same have been married to coin the term “theranosticsâ€?; it is gaining an increased momentum in the cancer field.
KW - Brain
KW - Diagnostic applications
KW - Magnetic
KW - Nanoparticle
KW - Site specific
KW - Targeting
UR - http://www.scopus.com/inward/record.url?scp=85046853296&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-813665-2.00005-3
DO - 10.1016/B978-0-12-813665-2.00005-3
M3 - Chapter
SN - 9780128136652
SP - 167
EP - 185
BT - Nanostructures for the Engineering of Cells, Tissues and Organs
PB - Elsevier
ER -