Brain globins in physiology and pathology

Luo Kun Xie, Shaohua Yang

Research output: Contribution to journalReview articleResearchpeer-review

7 Citations (Scopus)

Abstract

Globins are globular proteins for either transport or storage of oxygen which are critical for cellular metabolism. Four globins have been identified in rodent and human brains. Among them, neuroglobin, cytoglobin and hemoglobin chains are constitutively expressed in normal brain, while myoglobin is only expressed in some neurological disorders. Studies on the molecular structure, expression and functional features of these brain globins indicated that they may play crucial roles in maintenance of neural cell survival and activity, including neurons and astrocytes. Their regulation in neurological disorders may help thoroughly understand initiation and progression of ischemia, Alzheimer′s disease and glioma, etc. Elucidation of the brain globin functions might remarkably improve medical strategies that sustain neurological homeostasis and treat neurological diseases. Here the expression pattern and functions of brain globins and their involvement in neurological disorders are reviewed.

Original languageEnglish
Pages (from-to)154-163
Number of pages10
JournalMedical Gas Research
Volume6
Issue number3
DOIs
StatePublished - 1 Jul 2016

Fingerprint

Globins
Pathology
Nervous System Diseases
Brain
Myoglobin
Protein Transport
Molecular Structure
Glioma
Astrocytes
Rodentia
Cell Survival
Alzheimer Disease
Hemoglobins
Homeostasis
Ischemia
Maintenance
Oxygen
Neurons

Keywords

  • Brain
  • Cytoglobin
  • Hemoglobin
  • Ischemia
  • Myoglobin
  • Neurodegeneration
  • Neuroglobin
  • Neuroprotection

Cite this

Xie, Luo Kun ; Yang, Shaohua. / Brain globins in physiology and pathology. In: Medical Gas Research. 2016 ; Vol. 6, No. 3. pp. 154-163.
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Brain globins in physiology and pathology. / Xie, Luo Kun; Yang, Shaohua.

In: Medical Gas Research, Vol. 6, No. 3, 01.07.2016, p. 154-163.

Research output: Contribution to journalReview articleResearchpeer-review

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