Abstract
Imidazolidino[1,2-d]dithiadiazepines are converted to the ten-membered saturated heterocycles via borohydride reduction in acidic media or using "in situ" generated borane. Reductive alkylation in acetic or propionic acid as a solvent represents a significant side reaction. Relatively stable boron compounds are identified as intermediates which yield the saturated heterocycles upon acidic hydrolysis.
| Original language | English |
|---|---|
| Pages (from-to) | 4767-4772 |
| Number of pages | 6 |
| Journal | Tetrahedron |
| Volume | 48 |
| Issue number | 23 |
| DOIs | |
| State | Published - 5 Jun 1992 |
Keywords
- 1,2-dithia-5,8-diaza-cyclodecane
- Imidazolidino[1,2-d]dithiazepines
- borohydride reduction
- by-products
- reaction mechanism
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Cite this
Bodor, N., Koltai, E., & Prókai, L. (1992). Borohydride reduction of imidazolidino[1,2-d]dithiadiazepines. Tetrahedron, 48(23), 4767-4772. https://doi.org/10.1016/S0040-4020(01)81573-8