Abstract
Imidazolidino[1,2-d]dithiadiazepines are converted to the ten-membered saturated heterocycles via borohydride reduction in acidic media or using "in situ" generated borane. Reductive alkylation in acetic or propionic acid as a solvent represents a significant side reaction. Relatively stable boron compounds are identified as intermediates which yield the saturated heterocycles upon acidic hydrolysis.
Original language | English |
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Pages (from-to) | 4767-4772 |
Number of pages | 6 |
Journal | Tetrahedron |
Volume | 48 |
Issue number | 23 |
DOIs | |
State | Published - 5 Jun 1992 |
Keywords
- 1,2-dithia-5,8-diaza-cyclodecane
- Imidazolidino[1,2-d]dithiazepines
- borohydride reduction
- by-products
- reaction mechanism