Abstract
Aim: The aim of this study was to develop a novel cabazitaxel bone targeted nanoparticle (NP) system for improved drug delivery to the bone microenvironment. Materials & methods: Nanoparticles were developed using poly(D,L-lactic-co-glycolic acid) and cabazitaxel as the core with amino-bisphosphonate surface conjugation. Optimization of nanoparticle physiochemical properties, in vitro evaluation in prostate cancer cell lines and in vivo testing in an intraosseous model of metastatic prostate cancer was performed. Results: This bone targeted cabazitaxel nanocarrier system showed significant reduction in tumor burden, while at the same time maintaining bone structure integrity and reducing pain in the mouse tumor limb. Conclusion: This bone microenvironment targeted nanoparticle system and clinically relevant approach of evaluation represents a promising advancement for treating bone metastatic cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 2083-2095 |
| Number of pages | 13 |
| Journal | Nanomedicine |
| Volume | 12 |
| Issue number | 17 |
| DOIs | |
| State | Published - 1 Sep 2017 |
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Keywords
- bone metastasis
- cabazitaxel
- polymeric nanoparticle
- prostate cancer
- targeted therapeutic
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Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. / Gdowski, Andrew S.; Ranjan, Amalendu Prakash; Sarker, Marjana R.; Vishwanatha, Jamboor K.
In: Nanomedicine, Vol. 12, No. 17, 01.09.2017, p. 2083-2095.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain
AU - Gdowski, Andrew S.
AU - Ranjan, Amalendu Prakash
AU - Sarker, Marjana R.
AU - Vishwanatha, Jamboor K.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Aim: The aim of this study was to develop a novel cabazitaxel bone targeted nanoparticle (NP) system for improved drug delivery to the bone microenvironment. Materials & methods: Nanoparticles were developed using poly(D,L-lactic-co-glycolic acid) and cabazitaxel as the core with amino-bisphosphonate surface conjugation. Optimization of nanoparticle physiochemical properties, in vitro evaluation in prostate cancer cell lines and in vivo testing in an intraosseous model of metastatic prostate cancer was performed. Results: This bone targeted cabazitaxel nanocarrier system showed significant reduction in tumor burden, while at the same time maintaining bone structure integrity and reducing pain in the mouse tumor limb. Conclusion: This bone microenvironment targeted nanoparticle system and clinically relevant approach of evaluation represents a promising advancement for treating bone metastatic cancer.
AB - Aim: The aim of this study was to develop a novel cabazitaxel bone targeted nanoparticle (NP) system for improved drug delivery to the bone microenvironment. Materials & methods: Nanoparticles were developed using poly(D,L-lactic-co-glycolic acid) and cabazitaxel as the core with amino-bisphosphonate surface conjugation. Optimization of nanoparticle physiochemical properties, in vitro evaluation in prostate cancer cell lines and in vivo testing in an intraosseous model of metastatic prostate cancer was performed. Results: This bone targeted cabazitaxel nanocarrier system showed significant reduction in tumor burden, while at the same time maintaining bone structure integrity and reducing pain in the mouse tumor limb. Conclusion: This bone microenvironment targeted nanoparticle system and clinically relevant approach of evaluation represents a promising advancement for treating bone metastatic cancer.
KW - bone metastasis
KW - cabazitaxel
KW - polymeric nanoparticle
KW - prostate cancer
KW - targeted therapeutic
UR - http://www.scopus.com/inward/record.url?scp=85027682794&partnerID=8YFLogxK
U2 - 10.2217/nnm-2017-0190
DO - 10.2217/nnm-2017-0190
M3 - Article
VL - 12
SP - 2083
EP - 2095
JO - Nanomedicine
JF - Nanomedicine
SN - 1743-5889
IS - 17
ER -