Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain

Andrew S. Gdowski, Amalendu Ranjan, Marjana R. Sarker, Jamboor K. Vishwanatha

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Aim: The aim of this study was to develop a novel cabazitaxel bone targeted nanoparticle (NP) system for improved drug delivery to the bone microenvironment. Materials & methods: Nanoparticles were developed using poly(D,L-lactic-co-glycolic acid) and cabazitaxel as the core with amino-bisphosphonate surface conjugation. Optimization of nanoparticle physiochemical properties, in vitro evaluation in prostate cancer cell lines and in vivo testing in an intraosseous model of metastatic prostate cancer was performed. Results: This bone targeted cabazitaxel nanocarrier system showed significant reduction in tumor burden, while at the same time maintaining bone structure integrity and reducing pain in the mouse tumor limb. Conclusion: This bone microenvironment targeted nanoparticle system and clinically relevant approach of evaluation represents a promising advancement for treating bone metastatic cancer.

Original languageEnglish
Pages (from-to)2083-2095
Number of pages13
JournalNanomedicine
Volume12
Issue number17
DOIs
StatePublished - Sep 2017

Keywords

  • bone metastasis
  • cabazitaxel
  • polymeric nanoparticle
  • prostate cancer
  • targeted therapeutic

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