TY - JOUR
T1 - Bone morphogenetic proteins and their receptors in the eye
AU - Wordinger, Robert J.
AU - Clark, Abbot F.
N1 - Funding Information:
The authors acknowledge grant support (EY 012783) to R.J.W. from the National Eye Institute at the National Institutes of Health.
PY - 2007/9
Y1 - 2007/9
N2 - The human genome encodes at least 42 different members of the transforming growth factor-β superfamily of growth factors. Bone morphogenetic proteins (BMPs) are the largest subfamily of proteins within the transforming growth factor-β superfamily and are involved in numerous cellular functions including development, morphogenesis, cell proliferation, apoptosis, and extracellular matrix synthesis. This article first reviews BMPs and BMP receptors, BMP signaling pathways, and mechanisms controlling BMP signaling. Second, we review BMP and BMP receptor expression during embryonic ocular development/ differentiation and in adult ocular tissues. Lastly, future research directions with respect to BMP, BMP receptors, and ocular tissues are suggested.
AB - The human genome encodes at least 42 different members of the transforming growth factor-β superfamily of growth factors. Bone morphogenetic proteins (BMPs) are the largest subfamily of proteins within the transforming growth factor-β superfamily and are involved in numerous cellular functions including development, morphogenesis, cell proliferation, apoptosis, and extracellular matrix synthesis. This article first reviews BMPs and BMP receptors, BMP signaling pathways, and mechanisms controlling BMP signaling. Second, we review BMP and BMP receptor expression during embryonic ocular development/ differentiation and in adult ocular tissues. Lastly, future research directions with respect to BMP, BMP receptors, and ocular tissues are suggested.
KW - Bone morphogenetic protein receptors
KW - Bone morphogenetic protein signaling
KW - Bone morphogenetic proteins
KW - Ocular tissues
UR - http://www.scopus.com/inward/record.url?scp=34548444264&partnerID=8YFLogxK
U2 - 10.3181/0510-MR-345
DO - 10.3181/0510-MR-345
M3 - Short survey
C2 - 17720944
AN - SCOPUS:34548444264
SN - 1535-3702
VL - 232
SP - 979
EP - 992
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 8
ER -