TY - JOUR
T1 - Bone Marrow Adipocyte Developmental Origin and Biology
AU - Bukowska, Joanna
AU - Frazier, Trivia
AU - Smith, Stanley
AU - Brown, Theodore
AU - Bender, Robert
AU - McCarthy, Michelle
AU - Wu, Xiying
AU - Bunnell, Bruce A.
AU - Gimble, Jeffrey M.
N1 - Funding Information:
The authors thank Barbara Gawronska-Kozak Ph.D. for her critical review of the manuscript. This article is part of the Topical Collection on Bone Marrow and Adipose Tissue Xiying Wu and Smith report a patent on use of adipose cells in therapy in the submission process from LaCell LLC. Jeff Gimble is a co-founder and co-owner of Talaria Antibodies, a polyclonal antibody production company; Obatala Sciences, a fat on a chip technology; and is a co-founder, co-owner, and employee at LaCell LLC. Xiying Wu is a co-founder, co-owner, and R&D Director at LaCell LLC; a co-owner and co-founder of Obatala Sciences; and reports a patent on use of adipose cells in therapy in the submission process from LaCell LLC. Stanley Smith reports a patent on use of adipose cells in therapy in the submission process from LaCell LLC. Michelle McCarthy, Trivia Frazier, Joanna Bukowska, Theodore Brown, Robert Bender, and Bruce Bunnell declare no conflict of interest.
Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Purpose of Review: This review explores how the relationships between bone marrow adipose tissue (BMAT) adipogenesis with advancing age, obesity, and/or bone diseases (osteopenia or osteoporosis) contribute to mechanisms underlying musculoskeletal pathophysiology. Recent Findings: Recent studies have re-defined adipose tissue as a dynamic, vital organ with functions extending beyond its historic identity restricted solely to that of an energy reservoir or sink. “State of the art” methodologies provide novel insights into the developmental origin, physiology, and function of different adipose tissue depots. These include genetic tracking of adipose progenitors, viral vectors application, and sophisticated non-invasive imaging modalities. Summary: While constricted within the rigid bone cavity, BMAT vigorously contributes to local and systemic metabolic processes including hematopoiesis, osteogenesis, and energy metabolism and undergoes dynamic changes as a function of age, diet, bone topography, or sex. These insights will impact future research and therapies relating to osteoporosis.
AB - Purpose of Review: This review explores how the relationships between bone marrow adipose tissue (BMAT) adipogenesis with advancing age, obesity, and/or bone diseases (osteopenia or osteoporosis) contribute to mechanisms underlying musculoskeletal pathophysiology. Recent Findings: Recent studies have re-defined adipose tissue as a dynamic, vital organ with functions extending beyond its historic identity restricted solely to that of an energy reservoir or sink. “State of the art” methodologies provide novel insights into the developmental origin, physiology, and function of different adipose tissue depots. These include genetic tracking of adipose progenitors, viral vectors application, and sophisticated non-invasive imaging modalities. Summary: While constricted within the rigid bone cavity, BMAT vigorously contributes to local and systemic metabolic processes including hematopoiesis, osteogenesis, and energy metabolism and undergoes dynamic changes as a function of age, diet, bone topography, or sex. These insights will impact future research and therapies relating to osteoporosis.
KW - Beige cells
KW - Bone marrow
KW - Brown adipose tissue
KW - Cytomegalovirus
KW - White adipose tissue
UR - http://www.scopus.com/inward/record.url?scp=85045418845&partnerID=8YFLogxK
U2 - 10.1007/s11914-018-0442-z
DO - 10.1007/s11914-018-0442-z
M3 - Review article
C2 - 29667012
AN - SCOPUS:85045418845
VL - 16
SP - 312
EP - 319
JO - Current Osteoporosis Reports
JF - Current Osteoporosis Reports
SN - 1544-1873
IS - 3
ER -