TY - JOUR
T1 - Bone Marrow Adipocyte Developmental Origin and Biology
AU - Bukowska, Joanna
AU - Frazier, Trivia
AU - Smith, Stanley
AU - Brown, Theodore
AU - Bender, Robert
AU - McCarthy, Michelle
AU - Wu, Xiying
AU - Bunnell, Bruce A.
AU - Gimble, Jeffrey M.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Purpose of Review: This review explores how the relationships between bone marrow adipose tissue (BMAT) adipogenesis with advancing age, obesity, and/or bone diseases (osteopenia or osteoporosis) contribute to mechanisms underlying musculoskeletal pathophysiology. Recent Findings: Recent studies have re-defined adipose tissue as a dynamic, vital organ with functions extending beyond its historic identity restricted solely to that of an energy reservoir or sink. “State of the art” methodologies provide novel insights into the developmental origin, physiology, and function of different adipose tissue depots. These include genetic tracking of adipose progenitors, viral vectors application, and sophisticated non-invasive imaging modalities. Summary: While constricted within the rigid bone cavity, BMAT vigorously contributes to local and systemic metabolic processes including hematopoiesis, osteogenesis, and energy metabolism and undergoes dynamic changes as a function of age, diet, bone topography, or sex. These insights will impact future research and therapies relating to osteoporosis.
AB - Purpose of Review: This review explores how the relationships between bone marrow adipose tissue (BMAT) adipogenesis with advancing age, obesity, and/or bone diseases (osteopenia or osteoporosis) contribute to mechanisms underlying musculoskeletal pathophysiology. Recent Findings: Recent studies have re-defined adipose tissue as a dynamic, vital organ with functions extending beyond its historic identity restricted solely to that of an energy reservoir or sink. “State of the art” methodologies provide novel insights into the developmental origin, physiology, and function of different adipose tissue depots. These include genetic tracking of adipose progenitors, viral vectors application, and sophisticated non-invasive imaging modalities. Summary: While constricted within the rigid bone cavity, BMAT vigorously contributes to local and systemic metabolic processes including hematopoiesis, osteogenesis, and energy metabolism and undergoes dynamic changes as a function of age, diet, bone topography, or sex. These insights will impact future research and therapies relating to osteoporosis.
KW - Beige cells
KW - Bone marrow
KW - Brown adipose tissue
KW - Cytomegalovirus
KW - White adipose tissue
UR - http://www.scopus.com/inward/record.url?scp=85045418845&partnerID=8YFLogxK
U2 - 10.1007/s11914-018-0442-z
DO - 10.1007/s11914-018-0442-z
M3 - Review article
C2 - 29667012
AN - SCOPUS:85045418845
VL - 16
SP - 312
EP - 319
JO - Current Osteoporosis Reports
JF - Current Osteoporosis Reports
SN - 1544-1873
IS - 3
ER -