Blood pressure and cerebral blood flow oscillations: Friend or foe?

Caroline Alice Rickards, Yu Chieh Tzeng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Variability in arterial pressure and cerebral blood flow has traditionally been interpreted as a marker of cardiovascular decompensation, and has been associated with negative clinical outcomes across varying time scales, from impending orthostatic syncope to an increased risk of stroke. Emerging evidence, however, suggests that increased hemodynamic variability may, in fact, be protective in the face of acute challenges to perfusion, including significant central hypovolemia and hypotension (including hemorrhage), and during cardiac bypass surgery. We present the dichotomous views on the role of hemodynamic variability on clinical outcome, including the physiological mechanisms underlying these patterns, and the potential impact of increased and decreased variability on cerebral perfusion and oxygenation. We suggest that reconciliation of these two apparently discrepant views may lie in the time scale of hemodynamic variability; short time scale variability appears to be cerebroprotective, while mid to longer term fluctuations are associated with primary and secondary end-organ dysfunction.

Original languageEnglish
Title of host publication2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014
PublisherIEEE Computer Society
Pages179-180
Number of pages2
ISBN (Print)9781479939695
DOIs
StatePublished - 1 Jan 2014
Event2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014 - Trento, Italy
Duration: 25 May 201428 May 2014

Publication series

Name2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014

Other

Other2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014
CountryItaly
CityTrento
Period25/05/1428/05/14

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