TY - JOUR
T1 - Bisphenol A and metabolic syndrome
T2 - Results from NHANES
AU - Teppala, Srinivas
AU - Madhavan, Suresh
AU - Shankar, Anoop
PY - 2012
Y1 - 2012
N2 - Background. Bisphenol A (BPA) is detected in the urine of > 95% of US adults. Recent evidence from population-based studies suggests that BPA is associated with individual components for metabolic syndrome (MetS). However, no previous study has examined the direct association between BPA and MetS. Methods. We examined 2,104 participants from the National Health and Nutrition Examination Survey 2003-2008. The main outcome was the presence of MetS (n = 741). Results. Increasing levels of urinary BPA were positively associated with MetS, independent of confounders such as age, gender, race/ethnicity, smoking, alcohol intake, physical activity, and urinary creatinine. Compared to tertile 1 (referent), the multivariable adjusted odds ratio (95% confidence interval) of MetS in tertile 3 was 1.51 (1.07-2.12); P -trend was 0.02. Conclusions. Urinary BPA levels are positively associated with MetS, in a representative sample of US adults and independent of traditional risk factors for MetS. Future, prospective studies are needed to confirm our findings.
AB - Background. Bisphenol A (BPA) is detected in the urine of > 95% of US adults. Recent evidence from population-based studies suggests that BPA is associated with individual components for metabolic syndrome (MetS). However, no previous study has examined the direct association between BPA and MetS. Methods. We examined 2,104 participants from the National Health and Nutrition Examination Survey 2003-2008. The main outcome was the presence of MetS (n = 741). Results. Increasing levels of urinary BPA were positively associated with MetS, independent of confounders such as age, gender, race/ethnicity, smoking, alcohol intake, physical activity, and urinary creatinine. Compared to tertile 1 (referent), the multivariable adjusted odds ratio (95% confidence interval) of MetS in tertile 3 was 1.51 (1.07-2.12); P -trend was 0.02. Conclusions. Urinary BPA levels are positively associated with MetS, in a representative sample of US adults and independent of traditional risk factors for MetS. Future, prospective studies are needed to confirm our findings.
UR - http://www.scopus.com/inward/record.url?scp=84871364669&partnerID=8YFLogxK
U2 - 10.1155/2012/598180
DO - 10.1155/2012/598180
M3 - Article
C2 - 23251154
AN - SCOPUS:84871364669
SN - 1687-8337
VL - 2012
JO - International Journal of Endocrinology
JF - International Journal of Endocrinology
M1 - 598180
ER -