Biosynthesis of himastatin: Assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps

Junying Ma, Zhongwen Wang, Hongbo Huang, Minghe Luo, Dianguang Zuo, Bo Wang, Aijun Sun, Yi Qiang Cheng, Changsheng Zhang, Jianhua Ju

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

It's only natural: The biosynthetic pathway of himastatin from Streptomyces himastatinicus featuring unusual domain organizations is elucidated by genome scanning, generation of in-frame gene deletion mutants, and complementation experiments. Three cytochrome P450s that catalyze novel post-tailoring oxidative reactions (see picture) are characterized.

Original languageEnglish
Pages (from-to)7797-7802
Number of pages6
JournalAngewandte Chemie - International Edition
Volume50
Issue number34
DOIs
StatePublished - 16 Aug 2011

Keywords

  • C-C coupling
  • biosynthesis
  • cytochromes
  • natural products
  • peptides

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