It's only natural: The biosynthetic pathway of himastatin from Streptomyces himastatinicus featuring unusual domain organizations is elucidated by genome scanning, generation of in-frame gene deletion mutants, and complementation experiments. Three cytochrome P450s that catalyze novel post-tailoring oxidative reactions (see picture) are characterized.
|Number of pages||6|
|Journal||Angewandte Chemie - International Edition|
|State||Published - 16 Aug 2011|
- C-C coupling
- natural products