Abstract
It's only natural: The biosynthetic pathway of himastatin from Streptomyces himastatinicus featuring unusual domain organizations is elucidated by genome scanning, generation of in-frame gene deletion mutants, and complementation experiments. Three cytochrome P450s that catalyze novel post-tailoring oxidative reactions (see picture) are characterized.
Original language | English |
---|---|
Pages (from-to) | 7797-7802 |
Number of pages | 6 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 34 |
DOIs | |
State | Published - 16 Aug 2011 |
Keywords
- C-C coupling
- biosynthesis
- cytochromes
- natural products
- peptides