TY - JOUR
T1 - Biomarkers of aging
T2 - From primitive organisms to humans
AU - Butler, Robert N.
AU - Sprott, Richard
AU - Warner, Huber
AU - Bland, Jeffrey
AU - Feuers, Richie
AU - Forster, Michael
AU - Fillit, Howard
AU - Mitchell Harman, S.
AU - Hewitt, Michael
AU - Hyman, Mark
AU - Johnson, Kathleen
AU - Kligman, Evan
AU - McClearn, Gerald
AU - Nelson, James
AU - Richardson, Arlan
AU - Sonntag, William
AU - Weindiruch, Richard
AU - Wolf, Norman
PY - 2004/6
Y1 - 2004/6
N2 - Leading biologists and clinicians interested in aging convened to discuss biomarkers of aging. The goals were to come to a consensus, construct an agenda for future research, and make appropriate recommendations to policy makers and the public-at-large. While there was not total agreement on all issues, they addressed a number of questions, among them whether biomarkers can be identified and used to measure the physiological age of any individual within a population, given emerging information about aging and new technological advances. The hurdles to establishing informative biomarkers include the biological variation between individuals that makes generalizations difficult; the overlapping of aging and disease processes; uncertainty regarding benign versus pathogenic age-related changes; the point at which a process begins to do damage to the organism, and, if so, when does it occur; and when to distinguish critical damage from noncritical damage. Finally, and significantly, it is difficult to obtain funding for this research.
AB - Leading biologists and clinicians interested in aging convened to discuss biomarkers of aging. The goals were to come to a consensus, construct an agenda for future research, and make appropriate recommendations to policy makers and the public-at-large. While there was not total agreement on all issues, they addressed a number of questions, among them whether biomarkers can be identified and used to measure the physiological age of any individual within a population, given emerging information about aging and new technological advances. The hurdles to establishing informative biomarkers include the biological variation between individuals that makes generalizations difficult; the overlapping of aging and disease processes; uncertainty regarding benign versus pathogenic age-related changes; the point at which a process begins to do damage to the organism, and, if so, when does it occur; and when to distinguish critical damage from noncritical damage. Finally, and significantly, it is difficult to obtain funding for this research.
UR - http://www.scopus.com/inward/record.url?scp=3042755617&partnerID=8YFLogxK
M3 - Review article
C2 - 15215265
AN - SCOPUS:3042755617
SN - 1079-5006
VL - 59
SP - 560
EP - 567
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 6
ER -