Bilateral effects of unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in aged F344 rats

John A. Stanford, Michael Francis Salvatore, Barry M. Joyce, Hongyu Zhang, Don M. Gash, Greg A. Gerhardt

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Abstract

In order to determine its effects on locomotor-related striatal electrophysiology in aged rats, glial cell line-derived neurotrophic factor (GDNF) was infused (vehicle or 30 μg) into the right striatum of 24-25-month-old Fischer 344 (F344) rats. Multi-wire electrode arrays were then chronically implanted in striatum bilaterally. Thirty days later, striatal electrophysiological activity was recorded during freely moving conditions. Individual neurons were classified as locomotor-excited if they exhibited significant increases in firing rates during locomotor bouts versus periods of nonmovement. GDNF produced a significant increase in overall firing rates in locomotor-excited striatal neurons. This effect was observed in both the infused and the contralateral striatum. GDNF also attenuated the bursting activity of nonlocomotor-related striatal neurons, an effect that was also present bilaterally. These results suggest that GDNF's antiparkinsonism effects are associated with increased excitability of motor-related striatal neurons and diminished activity of neurons that do not exhibit explicit motor-related changes in activity. Such studies may aid in understanding the mechanism of potential therapies for movement disorders seen in aging and Parkinson's disease.

Original languageEnglish
Pages (from-to)156-165
Number of pages10
JournalNeurobiology of Aging
Volume28
Issue number1
DOIs
StatePublished - 1 Jan 2007

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Glial Cell Line-Derived Neurotrophic Factor
Corpus Striatum
Inbred F344 Rats
Neurons
Electrophysiology
Movement Disorders
Parkinson Disease
Electrodes

Keywords

  • Aging
  • Awake
  • Basal ganglia
  • Behaving
  • Dopamine
  • Electrophysiology
  • Freely moving
  • Multiunit
  • Neurotrophic
  • Striatum

Cite this

Stanford, John A. ; Salvatore, Michael Francis ; Joyce, Barry M. ; Zhang, Hongyu ; Gash, Don M. ; Gerhardt, Greg A. / Bilateral effects of unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in aged F344 rats. In: Neurobiology of Aging. 2007 ; Vol. 28, No. 1. pp. 156-165.
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Bilateral effects of unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in aged F344 rats. / Stanford, John A.; Salvatore, Michael Francis; Joyce, Barry M.; Zhang, Hongyu; Gash, Don M.; Gerhardt, Greg A.

In: Neurobiology of Aging, Vol. 28, No. 1, 01.01.2007, p. 156-165.

Research output: Contribution to journalArticleResearchpeer-review

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